Wnt Signaling Pathway Related Genes In Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is an extremely difficult disease to manage and one of the ten most common cancers in Malaysia. However, the molecular mechanisms that contribute to tumour progression in hepatocarcinogenesis remain unknown. In recent years, the evidence that the Wnt signaling pathw...
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| Format: | Thèse |
| Langue: | anglais anglais |
| Publié: |
2002
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| Accès en ligne: | http://psasir.upm.edu.my/id/eprint/11271/1/FPSK_P_2002_1.pdf |
| Résumé: | Hepatocellular carcinoma (HCC) is an extremely difficult disease to manage and one of
the ten most common cancers in Malaysia. However, the molecular mechanisms that
contribute to tumour progression in hepatocarcinogenesis remain unknown.
In recent years, the evidence that the Wnt signaling pathway may play a crucial role in
the hepatocarcinogenesis represents a major breakthrough. Despite efforts made in this
area of research, the relationship between the related genes of Wnt signaling pathway is
still far from comprehensive.
By employing immunohistochemistry and DNA sequencing, some related proteins and
genes of the Wnt signaling pathway were investigated in 23 paired HCC and adjacent
liver specimens from a tertiary referral centre in Malaysia. |
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