RNA interference silencing of interleukin-6 in mesenchymal stromal cells and antitumour efficacy against multiple myeloma cells

Studies demonstrated that mesenchymal stromal cells (MSC) from bone marrow (BM) stroma produced high concentrations of interleukin-6 (IL-6) that promoted multiple myeloma growth. In view of the failure of IL-6 monoclonal antibody therapy to demonstrate substantial clinical responses in early clinica...

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Détails bibliographiques

Auteur principal:	Teoh, Hoon Koon
Format:	Thèse
Langue:	anglais
Publié:	2015
Sujets:	RNA Interference - physiology RNAi Therapeutics - instrumentation Multiple Myeloma - microbiology
Accès en ligne:	http://psasir.upm.edu.my/id/eprint/64839/1/FPSK%28p%29%202015%2024.pdf