| Summary: | Metal complexes are widely prepared and have been successfully used in the
treatment of numerous human diseases including cancer. Organotin complexes are also
studied due to their potential biological activities such as anticancer, antihistamine,
antifungal, biocides and anti-fouling. In addition, Schiff base ligands derived from
substituted salicylaldehyde and substituted 2-hydroxyacetophenone are found to be
biologically active as anticancer and antimicrobial agents.
It is therefore the focus of this research project to investigate the variation of
biological activity of the diorganotin Schiff base complexes in relation to their
structures. In the present studies, several series of Schiff base ligands were prepared
with salicylaldehyde, substituted salicylaldehyde, 2-hydroxyacetophenone and
substituted 2-hydroxyacetophenone.
The diorganotin complexes were subsequently prepared by reacting the ligands
with diorganotin dichloride or oxide in 1:1 molar ratio and were characterized by
various spectroscopic methods including IR, NMR and UV spectroscopies. The
structures of the selected diorganotin complexes were determined by X-ray
crystallography and will be briefly discussed.
The in vitro cytotoxic activity of the Schiff base ligands and their diorganotin
complexes had been evaluated against several cancer cell-lines such as HT-29, SKOV-3
and MCF-7. In general, the cytotoxic activity test showed that the diorganotin
complexes had better cytotoxic activity as compared to the Schiff base ligands.
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