Molecular modelling of flaviviruses serine proteases for future drug development / Priyah A/P Narayanasamy

The flaviviruses are emerging arthropod-borne viruses that are important human pathogens and represent an immense global health problem. These enveloped, positive- stranded ribonucleic acid viruses can cause significant human diseases in the form of encephalitis or haemorrhagic fever. Some of the me...

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Auteur principal: Narayanasamy, Priyah
Format: Thèse
Publié: 2015
Sujets:
Q Science (General)
RM Therapeutics. Pharmacology
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author Narayanasamy, Priyah
author_facet Narayanasamy, Priyah
author_sort Narayanasamy, Priyah
description The flaviviruses are emerging arthropod-borne viruses that are important human pathogens and represent an immense global health problem. These enveloped, positive- stranded ribonucleic acid viruses can cause significant human diseases in the form of encephalitis or haemorrhagic fever. Some of the medically important flaviviruses are Dengue Virus (DEV), West Niles Virus (WNV), Japanese Encephalitis Virus (JEV), Yellow Fever Virus(YFV) and Hepatitis C Virus (HCV). There are no effective antiviral therapies are available to date and the main approach to disease control is via vaccination and vector control. Therefore focus on the development of anti viral target for drug development is crucial to treat the infection of flaviviruses. The viral protease and, NS3 and its cofactor, NS2B plays a major role in the cleavage of polyprotein during viral replication. Therefore, the understanding of residues interaction in flaviviruses protease has the potential to lead to drug discovery of flaviviruses infection.
format Thesis
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institution Universiti Malaya
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spelling oai:studentsrepo.um.edu.my:64132016-10-07T04:12:57Z Molecular modelling of flaviviruses serine proteases for future drug development / Priyah A/P Narayanasamy Narayanasamy, Priyah Q Science (General) RM Therapeutics. Pharmacology The flaviviruses are emerging arthropod-borne viruses that are important human pathogens and represent an immense global health problem. These enveloped, positive- stranded ribonucleic acid viruses can cause significant human diseases in the form of encephalitis or haemorrhagic fever. Some of the medically important flaviviruses are Dengue Virus (DEV), West Niles Virus (WNV), Japanese Encephalitis Virus (JEV), Yellow Fever Virus(YFV) and Hepatitis C Virus (HCV). There are no effective antiviral therapies are available to date and the main approach to disease control is via vaccination and vector control. Therefore focus on the development of anti viral target for drug development is crucial to treat the infection of flaviviruses. The viral protease and, NS3 and its cofactor, NS2B plays a major role in the cleavage of polyprotein during viral replication. Therefore, the understanding of residues interaction in flaviviruses protease has the potential to lead to drug discovery of flaviviruses infection. 2015 Thesis NonPeerReviewed application/pdf http://studentsrepo.um.edu.my/6413/1/1%2DMASTER_THESIS_TITLE_PAGE.pdf application/pdf http://studentsrepo.um.edu.my/6413/2/2%2D_ORIGINAL_LITERARY_WORK_DECLARATION.pdf application/pdf http://studentsrepo.um.edu.my/6413/3/3_MASTER_THESIS_ABSTRACT.pdf application/pdf http://studentsrepo.um.edu.my/6413/4/4__MASTER_THESIS_ABSTRAK.pdf application/pdf http://studentsrepo.um.edu.my/6413/5/5_MASTER_THESIS_ACKNOWLEDMENTS_(F)_.pdf application/pdf http://studentsrepo.um.edu.my/6413/6/6_MASTER_THESIS_TABLE_OF_CONTENTS%2D_pre.pdf application/pdf http://studentsrepo.um.edu.my/6413/7/7__MASTER_THESIS_LIST_OF_FIGURES.pdf application/pdf http://studentsrepo.um.edu.my/6413/8/8_MASTER_THESIS_LIST_OF_TABLES.pdf application/pdf http://studentsrepo.um.edu.my/6413/9/9__MASTER_THESIS_LIST_OF_SYMBOLS_AND_ABBREVIATION.pdf application/pdf http://studentsrepo.um.edu.my/6413/10/10__MASTER_THESIS_INTRODUCTION_(FP)__.pdf application/pdf http://studentsrepo.um.edu.my/6413/11/11__MASTER_THESIS_LITERATURE_REVIEW_2_(FP).pdf application/pdf http://studentsrepo.um.edu.my/6413/12/12__MASTER_THESIS_METHODOLOGY_.pdf application/pdf http://studentsrepo.um.edu.my/6413/13/13__MASTER_THESIS_RESULTS.pdf application/pdf http://studentsrepo.um.edu.my/6413/14/14_MASTER_THESIS_DISCUSSION.pdf application/pdf http://studentsrepo.um.edu.my/6413/15/15_MASTER_THESIS_CONCLUSION_AND_RECOMMENDATION.pdf application/pdf http://studentsrepo.um.edu.my/6413/16/16__MASTER_THESIS_REFERENCES.pdf application/pdf http://studentsrepo.um.edu.my/6413/17/17_Appendix.pdf Narayanasamy, Priyah (2015) Molecular modelling of flaviviruses serine proteases for future drug development / Priyah A/P Narayanasamy. Masters thesis, University of Malaya. http://studentsrepo.um.edu.my/6413/
spellingShingle Q Science (General)
RM Therapeutics. Pharmacology
Narayanasamy, Priyah
Molecular modelling of flaviviruses serine proteases for future drug development / Priyah A/P Narayanasamy
title Molecular modelling of flaviviruses serine proteases for future drug development / Priyah A/P Narayanasamy
title_full Molecular modelling of flaviviruses serine proteases for future drug development / Priyah A/P Narayanasamy
title_fullStr Molecular modelling of flaviviruses serine proteases for future drug development / Priyah A/P Narayanasamy
title_full_unstemmed Molecular modelling of flaviviruses serine proteases for future drug development / Priyah A/P Narayanasamy
title_short Molecular modelling of flaviviruses serine proteases for future drug development / Priyah A/P Narayanasamy
title_sort molecular modelling of flaviviruses serine proteases for future drug development priyah a p narayanasamy
topic Q Science (General)
RM Therapeutics. Pharmacology
url-record http://studentsrepo.um.edu.my/6413/
work_keys_str_mv AT narayanasamypriyah molecularmodellingofflavivirusesserineproteasesforfuturedrugdevelopmentpriyahapnarayanasamy

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