p53-Mdm2 interaction targeted therapy by Nutlin-3 on nasopharyngeal carcinoma cells / Voon Yee Lin
Nutlin-3, a small-molecule inhibitor of p53-Mdm2 interaction, is known to be effective against cancers expressing wild-type (wt) p53. p53 mutations are rare in nasopharyngeal carcinoma (NPC), and hence targeting the disruption of p53-Mdm2 interaction to reactivate p53 may offer a promising therap...
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| 格式: | Thesis |
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2016
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