Aurones Of Amine And Carbamate Functionalities As Neuroprotective Agents With Multitargeting Potential: Synthesis, Structure-Activity Relationships And Mode Of Action Studies
Penyakit Alzheimer (AD) ialah penyakit kompleks pelbagai faktor melibatkan pelbagai mekanisme yang menyumbang kepada pencetusan penyakit ini. Dalam pencarian entiti kimia baru untuk menangani faktor-faktor penyebab penyakit ini, strategi rekaan ligan diarah pelbagai sasaran (MTDL) telah digunakan...
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | أطروحة |
| اللغة: | الإنجليزية |
| منشور في: |
2016
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://eprints.usm.my/31611/ |
| Abstract | Abstract here |
| _version_ | 1854967251465142272 |
|---|---|
| author | Liew , Kok Fui |
| author_facet | Liew , Kok Fui |
| author_sort | Liew , Kok Fui |
| description | Penyakit Alzheimer (AD) ialah penyakit kompleks pelbagai faktor melibatkan
pelbagai mekanisme yang menyumbang kepada pencetusan penyakit ini. Dalam
pencarian entiti kimia baru untuk menangani faktor-faktor penyebab penyakit ini,
strategi rekaan ligan diarah pelbagai sasaran (MTDL) telah digunakan dalam kajian
ini dengan menggabungkan motif struktur yang terpilih (pelbagai amina dan
karbamat) daripada dua ubat Alzheimer yang mantap (donepezil dan rivastigmina) ke
dalam perancah auron.
Alzheimer’s disease (AD) is a complex multifactorial disease involving diverse
mechanisms contributing to the onset of the disease. In the search for novel chemical
entities to address the causative factors of the disease, the multitarget-directed ligand
(MTDL) design strategy has been applied in the present study by incorporating
selected structural motifs (various amines and carbamate) from two established
Alzheimer drugs (donepezil and rivastigmine) into the aurone scaffold. |
| first_indexed | 2025-10-17T08:08:28Z |
| format | Thesis |
| id | usm-31611 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-10-17T08:08:28Z |
| publishDate | 2016 |
| record_format | eprints |
| record_pdf | Abstract |
| spelling | usm-316112019-04-12T05:25:20Z http://eprints.usm.my/31611/ Aurones Of Amine And Carbamate Functionalities As Neuroprotective Agents With Multitargeting Potential: Synthesis, Structure-Activity Relationships And Mode Of Action Studies Liew , Kok Fui RS1-441 Pharmacy and materia medica Penyakit Alzheimer (AD) ialah penyakit kompleks pelbagai faktor melibatkan pelbagai mekanisme yang menyumbang kepada pencetusan penyakit ini. Dalam pencarian entiti kimia baru untuk menangani faktor-faktor penyebab penyakit ini, strategi rekaan ligan diarah pelbagai sasaran (MTDL) telah digunakan dalam kajian ini dengan menggabungkan motif struktur yang terpilih (pelbagai amina dan karbamat) daripada dua ubat Alzheimer yang mantap (donepezil dan rivastigmina) ke dalam perancah auron. Alzheimer’s disease (AD) is a complex multifactorial disease involving diverse mechanisms contributing to the onset of the disease. In the search for novel chemical entities to address the causative factors of the disease, the multitarget-directed ligand (MTDL) design strategy has been applied in the present study by incorporating selected structural motifs (various amines and carbamate) from two established Alzheimer drugs (donepezil and rivastigmine) into the aurone scaffold. 2016-06 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/31611/1/Liew_Kok_Fui.pdf Liew , Kok Fui (2016) Aurones Of Amine And Carbamate Functionalities As Neuroprotective Agents With Multitargeting Potential: Synthesis, Structure-Activity Relationships And Mode Of Action Studies. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Liew , Kok Fui Aurones Of Amine And Carbamate Functionalities As Neuroprotective Agents With Multitargeting Potential: Synthesis, Structure-Activity Relationships And Mode Of Action Studies |
| title | Aurones Of Amine And Carbamate
Functionalities As Neuroprotective
Agents With Multitargeting
Potential: Synthesis,
Structure-Activity Relationships And
Mode Of Action Studies |
| title_full | Aurones Of Amine And Carbamate
Functionalities As Neuroprotective
Agents With Multitargeting
Potential: Synthesis,
Structure-Activity Relationships And
Mode Of Action Studies |
| title_fullStr | Aurones Of Amine And Carbamate
Functionalities As Neuroprotective
Agents With Multitargeting
Potential: Synthesis,
Structure-Activity Relationships And
Mode Of Action Studies |
| title_full_unstemmed | Aurones Of Amine And Carbamate
Functionalities As Neuroprotective
Agents With Multitargeting
Potential: Synthesis,
Structure-Activity Relationships And
Mode Of Action Studies |
| title_short | Aurones Of Amine And Carbamate
Functionalities As Neuroprotective
Agents With Multitargeting
Potential: Synthesis,
Structure-Activity Relationships And
Mode Of Action Studies |
| title_sort | aurones of amine and carbamate functionalities as neuroprotective agents with multitargeting potential synthesis structure activity relationships and mode of action studies |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/31611/ |
| work_keys_str_mv | AT liewkokfui auronesofamineandcarbamatefunctionalitiesasneuroprotectiveagentswithmultitargetingpotentialsynthesisstructureactivityrelationshipsandmodeofactionstudies |