Synthesis And Biological Activity Of Benzimidazole Analogs As Sirtuin Enzyme Inhibitors

Bagi mencari perencat enzim sirtuin yang poten, 90 analog benzimidazol telah berjaya direka.Kaedah sintesis yang digunakan dalam projek ini mengambilkira langkah-langkah yang lestari.Sebatian4h (ethyl 2-(4-(piperidin-1-yl)phenyl)-1H-benzo[d]imidazole-5-carboxylate)merupakanperencat enzim sirtuin yan...

Full description

Bibliographic Details
Main Author:	Yeong, Keng Yoon
Format:	Thesis
Language:	English
Published:	2016
Subjects:	R735-854 Medical education. Medical schools. Research
Online Access:	http://eprints.usm.my/32341/
Abstract	Abstract here

Similar Items

A Novel Inhibitor Of Sirtuin: Elucidation Of Mode Of Action And Molecular Pathway In Colorectal Cancer Cell Line
by: Tan, Yi Jer
Published: (2017)

Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
by: Cheah, Hong Leong
Published: (2014)

Synthesis, Biological Activity And Molecular Docking Of Imidazole-Phenazine Derivatives As Potential Inhibitors For Ns2b-Ns3 Dengue Protease
by: Khalili, Nur Sarah Dyana
Published: (2024)

Computational Design And Synthesis Of Potential Ns2b-Ns3 Dengue Protease Inhibitors
by: Salin, Nurul Hanim
Published: (2024)

Isolation And Selective Reduction Of Mitragynine, Synthesis And Characterization Of New Indole Derivatives And Their Selected Biological Activity Studies
by: Goh, Teik Beng
Published: (2015)

Characterization of the anti-angiogenesis activity of labisia pumila and identification of its molecular constituents that contribute to its biological activity.
by: Samad, Nozlena Abdul
Published: (2010)

Daily Rhythms In Insecticide Susceptibility, Metabolic Enzyme Activity And Gene Expression In The Common Bed Bug, Cimex lectularius L. (Hemiptera: Cimicidae)
by: Khalid, Muhammad Fazli
Published: (2020)

Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
by: Lee , Yie Vern
Published: (2017)

High Throughput Virtual Screening For Inhibitors Of Salmonella typhi’s Dalanine- D-Alanine Ligase A
by: Tan, Chen Shen
Published: (2015)

Effect Of Galactose And Fructose On The Expression Of Isocitrate Lyase (ICL1) Enzyme In Candida Albicans
by: Ting, Seng Yeat
Published: (2016)

Genetic Polymorphisms In The Phase I And Phase II Xenobiotic Metabolizing Enzymes In Malaysian Population And Their Influence On Colorectal Cancer Susceptibility
by: Shahpudin, Siti Nurfatimah Mohd
Published: (2012)

Synthesis And Characterisation Of Silver Nanoparticles Using Vernonia cinerea Aqueous Extract And Their Cytotoxic Activity Against Kasumi-1 Cell Line
by: Mohamad Zani, Radhiyatul Akma
Published: (2016)

The Effects Of Angiotensin Iconverting Enzyme (ACE) I/D And Alphaactinin- 3 (ACTN3) R/X Gene Polymorphisms On Human Physical Performance And Health Within Malaysian Population
by: Yusof @ Hanafi, Hazwani Ahmad
Published: (2016)

In Vitro Evaluation Of Antifungal, Antioxidant And Cytotoxicity Activity Of Couroupita Guianensis With Identification Of Antifungal Active Fraction
by: Sivapragasam, Gothai
Published: (2015)

Synthesis And Characterisation Of PEG-PLGA Nanoparticles For Geraniin Isolated From Phyllanthus watsonii (Dukung Anak) Extract
by: Jairaman, Sreegayathri
Published: (2018)

In Vitro Cytotoxicity Activity And In Vivo Oral Toxicity Of Euphorbia hirta
by: Kwan, Yuet Ping
Published: (2014)

Evaluation Of Antimicrobial Activity Of Eclipta Alba Leaf Extract For Food Preservation
by: Rajandran, R. Kushha
Published: (2020)

Synthesis And Characterization Of Phenyl Functionalized Magnetic Nanoparticles As Sorbent In Micro-Solid Phase Extraction Of Polycyclic Aromatic Hyrocarbons And Organophosphorus Pesticides
by: Hassan, Farah Wahidah Mohd
Published: (2018)

Antimicrobial, Anticancer And Antioxidant Activities Of Methanolic Extract Of Elaeis Guineensis Jacq. Leaves
by: Soundararajan, Vijayarathna
Published: (2012)

Caloric Content Has Greater Level Of Brain Activation During Carbohydrate Mouth Rinsing
by: Abu Bakar, Al-Hafiz
Published: (2017)

Screening Of Agro-Wastes As Growth Substrate, Quantification And Antimicrobial Activity Of Bioactive Metabolites Of Lactobacillus Species
by: Ali Hassan, Hassan Pyar
Published: (2015)

Anti-Candidal Activity And Toxicity Studies Of Alginate-Enclosed Chitosan–Calcium Phosphate-Loaded Fe-Bovine Lactoferrin Nanocapsules
by: Khoo, Miew Leng
Published: (2018)

Effects Of Chrysin On The mRNA Expression Of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) And Cyp Genes, Cell Cycle And Cell Migration In Colorectal Cancer Hct-116 Cells
by: Khor, Chin Yin
Published: (2020)

A comparative study on the effectiveness of adjunct online learning tool between conventional and gamified e-learning in enhancing electrocardiogram competency among medical students
by: May Honey Ohn
Published: (2019)

Identification Of Salmonella Enterica Subspecies Enterica Serovar Typhi-Specific Genes For The Development Of Dna-Based And Antibody-Based Diagnostics For Typhoid Fever
by: Goay , Yuan Xin
Published: (2018)

Detection And Identification Of Circulating Toxoplasma Gondii Antigens And Host Specific Proteins In Toxoplasmosis Via Serum Proteomic Approach
by: Osman, Emelia
Published: (2010)

Construction Of Human Lymphatic Filariasis Antibody Phage Display Library And Production Of Recombinant Monoclonal Antibodies Against BmR1 And BmSXP Filarial Antigens
by: Rahumatullah, Anizah
Published: (2018)

Functional Characterization Of The Outer Membrane Protein TolC of Salmonella enterica subspecies enterica serovar Typhi And Its Association With Virulence
by: Hussain, Ashraf
Published: (2018)

Innovative Approaches Towards Development And Utilization Of Dna Diagnostics For Salmonella Typhi.
by: Ismail, Aziah
Published: (2009)

Experimental Rnomics: Towards The Identification And Characterization Of Non-Protein-Coding Ribonucleic Acids In Pathogenic Agent, Salmonella Typhi
by: Zakaria, Robaiza
Published: (2008)

Study On The Involvement Of Wif-1 In Oral Carcinogenesis Via Egfr And Wnt Signaling Pathways
by: Chow , Tan Wei
Published: (2015)

Identification And Characterization Of Protein Markers And Development Of Immunoassay For The Detection Of Hydatid Cyst Disease
by: Moghadam Kakhki, Zohreh Kazemi
Published: (2015)

In-Vivo Induced Antigens Of Toxoplasma Gondii And Their Application In Diagnosis Of Human Toxoplasmosis
by: Amerizadeh, Atefeh
Published: (2015)

Studies Of Clitoria Ternatea Linn. Root Extract On Behavioural Effects And In Vivo Hippocampal Synaptic Plasticity In A Rat Model Of Chronic Cerebral Hypoperfusion
by: Damodaran, Thenmoly K
Published: (2018)

Development Of HSPX Vaccine Against Latent Tuberculosis Using Adjuvant-Dependent T-Helper Alternating Peptide Strategy
by: Lew, Min Han
Published: (2020)

Cell-Based Therapy Of Human Adipose- Derived Mesenchymal Stem Cell Expressing Angiopoietin-1 In An Experimental Model Of Airway Inflammation
by: Halim, Nur Shuhaidatul Sarmiza Abdul
Published: (2018)

Analysis of Toxoplasma gondii excretory secretory antigens (ESA) And identification of Potential markers of acute infection.
by: Saadatnia, Geita
Published: (2011)

Effects of cross-fostering and Melatonin supplementation on the Development of hypertension and Renal antioxidant/oxidant system in Spontaneously hypertensive rats.
by: Lee, Siew Keah
Published: (2011)

Development Of Fӧrster Resonance Energy Transfer Based Homogeneous Immunoassays For Determination Of (R)-Methadone
by: Ooi, May Yui
Published: (2016)

Identification Of Potential Toxoplasma Gondii cDNA Phage Clones And Production Of The Corresponding Recombinant Proteins In The Development Of IgG Avidity Assay For Serodiagnosis Of Toxoplasmosis
by: Teh, Ai Ying
Published: (2016)