Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells
Cytokines, like IL-6, play an important role in triggering the acute phase response (APR) of the body to injury and inflammation. The dynamics of expression and interaction of the IL-6 signalling pathway components in the regulation of peroxisome proliferator-activated receptor alpha (PPARα) during...
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | أطروحة |
| اللغة: | الإنجليزية |
| منشور في: |
2010
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://eprints.usm.my/41719/ |
| _version_ | 1846216270488272896 |
|---|---|
| author | Chew , Guat Siew |
| author_facet | Chew , Guat Siew |
| author_sort | Chew , Guat Siew |
| description | Cytokines, like IL-6, play an important role in triggering the acute phase response (APR) of the body to injury and inflammation. The dynamics of expression and interaction of the IL-6 signalling pathway components in the regulation of peroxisome proliferator-activated receptor alpha (PPARα) during APR remain to be properly identified. In this study, we determined that three possible potential signaling pathways, JAK-STAT, PI3K and MAPK (p38 and ERK1/2) which derived from the upstream JAK and SHP2 components of the IL-6 signalling were involved in IL-6-inhibitory effect on PPARα gene expression. |
| first_indexed | 2025-10-17T08:17:19Z |
| format | Thesis |
| id | usm-41719 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-10-17T08:17:19Z |
| publishDate | 2010 |
| record_format | eprints |
| spelling | usm-417192019-04-12T05:26:49Z http://eprints.usm.my/41719/ Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells Chew , Guat Siew QH1 Natural history (General - Including nature conservation, geographical distribution) Cytokines, like IL-6, play an important role in triggering the acute phase response (APR) of the body to injury and inflammation. The dynamics of expression and interaction of the IL-6 signalling pathway components in the regulation of peroxisome proliferator-activated receptor alpha (PPARα) during APR remain to be properly identified. In this study, we determined that three possible potential signaling pathways, JAK-STAT, PI3K and MAPK (p38 and ERK1/2) which derived from the upstream JAK and SHP2 components of the IL-6 signalling were involved in IL-6-inhibitory effect on PPARα gene expression. 2010-09 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/41719/1/CHEW_GUAT_SIEW.pdf Chew , Guat Siew (2010) Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | QH1 Natural history (General - Including nature conservation, geographical distribution) Chew , Guat Siew Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells |
| title | Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells |
| title_full | Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells |
| title_fullStr | Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells |
| title_full_unstemmed | Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells |
| title_short | Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells |
| title_sort | molecular mechanism of acute phase response identification of signal transduction pathways mediating cytokine inhibitory effect on human peroxisome proliferator activated receptor alpha ppara in liver cells |
| topic | QH1 Natural history (General - Including nature conservation, geographical distribution) |
| url | http://eprints.usm.my/41719/ |
| work_keys_str_mv | AT chewguatsiew molecularmechanismofacutephaseresponseidentificationofsignaltransductionpathwaysmediatingcytokineinhibitoryeffectonhumanperoxisomeproliferatoractivatedreceptoralphapparainlivercells |