Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
The low permeability of the cell envelope against hydrophilic anti-tuberculosis (TB) drugs especially isoniazid (INH), is one of the crucial factors that contribute to the intrinsic resistance in Mycobacterium tuberculosis. Previous studies have floated the idea that the anti-mycobacterial activity...
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| フォーマット: | 学位論文 |
| 言語: | 英語 |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | http://eprints.usm.my/42806/ |
| Abstract | Abstract here |
| 要約: | The low permeability of the cell envelope against hydrophilic anti-tuberculosis (TB) drugs especially isoniazid (INH), is one of the crucial factors that contribute to the intrinsic resistance in Mycobacterium tuberculosis. Previous studies have floated the idea that the anti-mycobacterial activity of INH can be enhanced by augmenting the hydrophilic INH into a hydrophobic/lipophilic compound. Therefore, a series of 13 derivatives with different hydrophobicity were synthesized by adding different hydrophobic acyl chain to the parent compound, INH. |
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