Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma

• المؤلف الرئيسي: Khare, Vani
• التنسيق: أطروحة
• اللغة: الإنجليزية
• منشور في: 2013
• الموضوعات: QH1 Natural history (General - Including nature conservation, geographical distribution)
• الوصول للمادة أونلاين: http://eprints.usm.my/43997/

Prostaglandins are required for the successful development and functioning of the female reproductive system in vertebrates. The synthesis of prostaglandin relies on the catalytic activities of two cyclooxygenase isoforms (COX-1 and COX-2). Various reports emphasize that both COX isoforms are essential for the production of prostaglandin during various stages of oogenesis, such as oocyte growth, maturation and ovulation. In comparison to COX-2, there is a paucity of knowledge on the role of COX-1, especially in oogenesis. At the same time, while COX-2 is a well established marker in ovulation, its function in growth and maturation of oocyte requires further exploration. This study, thereby, distinguishes the role of COX-1 and COX-2 during zebrafish oocyte growth and maturation, firstly by examining the mRNA expression of both the isoforms in these oocyte stages. An increase in zebrafish follicle COX-1 mRNA expression was observed as the oocytes develop and mature.