Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia
Repeated Pregnancy Loss (RPL) is a prevalent condition where conventional hereditary thrombophilia factors have been ruled out in Malaysia population. M2/ANXA5 haplotype, a variation at the core promoter region of Annexin A5 (ANXA5) gene, was suggested to be a predisposition factor for RPL. ANXA5 is...
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| Format: | Thesis |
| Language: | English |
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2018
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| Online Access: | http://eprints.usm.my/44014/ |
| Abstract | Abstract here |
| _version_ | 1855629789375758336 |
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| author | Ang, Kai Cheen |
| author_facet | Ang, Kai Cheen |
| author_sort | Ang, Kai Cheen |
| description | Repeated Pregnancy Loss (RPL) is a prevalent condition where conventional hereditary thrombophilia factors have been ruled out in Malaysia population. M2/ANXA5 haplotype, a variation at the core promoter region of Annexin A5 (ANXA5) gene, was suggested to be a predisposition factor for RPL. ANXA5 is a placenta anticoagulant protein which binds on the surface of syncitiotrophoblasts to prevent thrombotic events that would lead to RPL. In this study, the prevalence of M2/ANXA5 haplotype was 42.2% in Malay population and 34.9% for parous controls. When compared M2/ANXA5 clinically defined primary and secondary RPL carriers to M2/ANXA5 carriers in random populations, odds ratio of 1.52 (95% CI:1.1 to 2.1) was determined. |
| first_indexed | 2025-10-17T08:23:51Z |
| format | Thesis |
| id | usm-44014 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-10-17T08:23:51Z |
| publishDate | 2018 |
| record_format | EPrints |
| record_pdf | Restricted |
| spelling | usm-440142019-04-12T05:24:50Z http://eprints.usm.my/44014/ Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia Ang, Kai Cheen R5-920 Medicine (General) Repeated Pregnancy Loss (RPL) is a prevalent condition where conventional hereditary thrombophilia factors have been ruled out in Malaysia population. M2/ANXA5 haplotype, a variation at the core promoter region of Annexin A5 (ANXA5) gene, was suggested to be a predisposition factor for RPL. ANXA5 is a placenta anticoagulant protein which binds on the surface of syncitiotrophoblasts to prevent thrombotic events that would lead to RPL. In this study, the prevalence of M2/ANXA5 haplotype was 42.2% in Malay population and 34.9% for parous controls. When compared M2/ANXA5 clinically defined primary and secondary RPL carriers to M2/ANXA5 carriers in random populations, odds ratio of 1.52 (95% CI:1.1 to 2.1) was determined. 2018-06 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44014/1/ANG%20KAI%20CHEEN.pdf Ang, Kai Cheen (2018) Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | R5-920 Medicine (General) Ang, Kai Cheen Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia |
| thesis_level | PhD |
| title | Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia |
| title_full | Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia |
| title_fullStr | Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia |
| title_full_unstemmed | Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia |
| title_short | Genetic Predisposition Of M2 Annexin A5 Haplotype In Recurrent Pregnancy Loss Among The Malays In Malaysia |
| title_sort | genetic predisposition of m2 annexin a5 haplotype in recurrent pregnancy loss among the malays in malaysia |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/44014/ |
| work_keys_str_mv | AT angkaicheen geneticpredispositionofm2annexina5haplotypeinrecurrentpregnancylossamongthemalaysinmalaysia |