Formulation And Evaluation Of Self-Emulsifying Drug Delivery Systems Of Azithromycin To Enhance Its Penetration Through The Epithelial Tight Junctions
Azithromycin (AZM) is a macrolide antibiotic used for the treatment of a number of bacterial infections. It is known to have a low oral bioavailability (37 %) due to its relatively high molecular weight, incomplete solubility and/or poor intestinal permeability, which is potentially restricting its...
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| Format: | Thesis |
| Language: | English |
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2018
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| Online Access: | http://eprints.usm.my/44259/ |
| Abstract | Abstract here |
| _version_ | 1855632280963252224 |
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| author | Assi, Reem Abou |
| author_facet | Assi, Reem Abou |
| author_sort | Assi, Reem Abou |
| description | Azithromycin (AZM) is a macrolide antibiotic used for the treatment of a number of bacterial infections. It is known to have a low oral bioavailability (37 %) due to its relatively high molecular weight, incomplete solubility and/or poor intestinal permeability, which is potentially restricting its intestinal absorption. To overcome these drawbacks liquid and solid self-emulsifying drug delivery systems (L-SEDDs and S-SEDDs) of AZM were prepared in an attempt to enhance its solubility, and altering its cellular penetration, which might improve its oral bioavailability. |
| first_indexed | 2025-10-17T08:24:23Z |
| format | Thesis |
| id | usm-44259 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-10-17T08:24:23Z |
| publishDate | 2018 |
| record_format | EPrints |
| record_pdf | Restricted |
| spelling | usm-442592019-05-06T01:39:00Z http://eprints.usm.my/44259/ Formulation And Evaluation Of Self-Emulsifying Drug Delivery Systems Of Azithromycin To Enhance Its Penetration Through The Epithelial Tight Junctions Assi, Reem Abou RS1-441 Pharmacy and materia medica Azithromycin (AZM) is a macrolide antibiotic used for the treatment of a number of bacterial infections. It is known to have a low oral bioavailability (37 %) due to its relatively high molecular weight, incomplete solubility and/or poor intestinal permeability, which is potentially restricting its intestinal absorption. To overcome these drawbacks liquid and solid self-emulsifying drug delivery systems (L-SEDDs and S-SEDDs) of AZM were prepared in an attempt to enhance its solubility, and altering its cellular penetration, which might improve its oral bioavailability. 2018-03 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44259/1/REEM%20ABOU%20ASSI.pdf Assi, Reem Abou (2018) Formulation And Evaluation Of Self-Emulsifying Drug Delivery Systems Of Azithromycin To Enhance Its Penetration Through The Epithelial Tight Junctions. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Assi, Reem Abou Formulation And Evaluation Of Self-Emulsifying Drug Delivery Systems Of Azithromycin To Enhance Its Penetration Through The Epithelial Tight Junctions |
| thesis_level | Master |
| title | Formulation And Evaluation Of Self-Emulsifying Drug Delivery Systems Of Azithromycin To Enhance Its Penetration Through The Epithelial Tight Junctions |
| title_full | Formulation And Evaluation Of Self-Emulsifying Drug Delivery Systems Of Azithromycin To Enhance Its Penetration Through The Epithelial Tight Junctions |
| title_fullStr | Formulation And Evaluation Of Self-Emulsifying Drug Delivery Systems Of Azithromycin To Enhance Its Penetration Through The Epithelial Tight Junctions |
| title_full_unstemmed | Formulation And Evaluation Of Self-Emulsifying Drug Delivery Systems Of Azithromycin To Enhance Its Penetration Through The Epithelial Tight Junctions |
| title_short | Formulation And Evaluation Of Self-Emulsifying Drug Delivery Systems Of Azithromycin To Enhance Its Penetration Through The Epithelial Tight Junctions |
| title_sort | formulation and evaluation of self emulsifying drug delivery systems of azithromycin to enhance its penetration through the epithelial tight junctions |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/44259/ |
| work_keys_str_mv | AT assireemabou formulationandevaluationofselfemulsifyingdrugdeliverysystemsofazithromycintoenhanceitspenetrationthroughtheepithelialtightjunctions |