Significance of zone 2 peak on capillary electrophoresis for the detection of haemoglobin constant spring

Haemoglobin Constant Spring (Hb CS) is a point mutational defect of α thalassaemia at the termination codon and leads to α chain extension and reduced mRNA stability. It is a prevalent and common non deletional α thalassemia in most Southeast Asian countries. This abnormal haemoglobin has clinica...

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