Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population
Loss of heterozygosity (LOH) and microsatellite instability (MSI) have been documented as important events of oral squamous cell carcinoma (OSCC). Five microsatellite markers D3S192, D3S966, D3S647, D3S1228 and D3S659 were selected on chromosome 3p because of high frequency of alterations reported i...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2012
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/44816/ |
| Abstract | Abstract here |
| _version_ | 1855632326582599680 |
|---|---|
| author | Jusoh, Julia Ashaliza Mat |
| author_facet | Jusoh, Julia Ashaliza Mat |
| author_sort | Jusoh, Julia Ashaliza Mat |
| description | Loss of heterozygosity (LOH) and microsatellite instability (MSI) have been documented as important events of oral squamous cell carcinoma (OSCC). Five microsatellite markers D3S192, D3S966, D3S647, D3S1228 and D3S659 were selected on chromosome 3p because of high frequency of alterations reported in head and neck squamous cell carcinoma and the involvement of VHL (von Hippel Lindau) at 3p25-26 and the FHIT (fragile histidine triad) at 3p14.2 genes proven in many tumor types. A total of 50 archival tissue samples of OSCC and corresponding normal samples were analyzed for LOH and MSI status. The overall LOH for the markers selected on 3p was 56 out of 189 informative cases (29.6%). |
| first_indexed | 2025-10-17T08:25:21Z |
| format | Thesis |
| id | usm-44816 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-10-17T08:25:21Z |
| publishDate | 2012 |
| record_format | EPrints |
| record_pdf | Restricted |
| spelling | usm-448162019-07-02T07:11:02Z http://eprints.usm.my/44816/ Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population Jusoh, Julia Ashaliza Mat RK1-715 Dentistry Loss of heterozygosity (LOH) and microsatellite instability (MSI) have been documented as important events of oral squamous cell carcinoma (OSCC). Five microsatellite markers D3S192, D3S966, D3S647, D3S1228 and D3S659 were selected on chromosome 3p because of high frequency of alterations reported in head and neck squamous cell carcinoma and the involvement of VHL (von Hippel Lindau) at 3p25-26 and the FHIT (fragile histidine triad) at 3p14.2 genes proven in many tumor types. A total of 50 archival tissue samples of OSCC and corresponding normal samples were analyzed for LOH and MSI status. The overall LOH for the markers selected on 3p was 56 out of 189 informative cases (29.6%). 2012-05 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44816/1/JULIA%20ASHAZILA%20BINTI%20MAT%20JUSOH.pdf Jusoh, Julia Ashaliza Mat (2012) Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | RK1-715 Dentistry Jusoh, Julia Ashaliza Mat Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population |
| thesis_level | Master |
| title | Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population |
| title_full | Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population |
| title_fullStr | Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population |
| title_full_unstemmed | Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population |
| title_short | Microsatellite Instability And Loss Of Heterozygosity In Oral Squamous Cell Carcinoma In A Malaysian Population |
| title_sort | microsatellite instability and loss of heterozygosity in oral squamous cell carcinoma in a malaysian population |
| topic | RK1-715 Dentistry |
| url | http://eprints.usm.my/44816/ |
| work_keys_str_mv | AT jusohjuliaashalizamat microsatelliteinstabilityandlossofheterozygosityinoralsquamouscellcarcinomainamalaysianpopulation |