Genetic Polymorphisms Of Inflammation Response Genes And Their Influence On Malaysian Colorectal Cancer Patients : A Case Control Study

• मुख्य लेखक: Mustapha, Mohd Aminudin
• स्वरूप: थीसिस
• भाषा: अंग्रेज़ी
• प्रकाशित: 2012
• विषय: R5-920 Medicine (General)
• ऑनलाइन पहुंच: http://eprints.usm.my/44844/

Sporadic colorectal cancer (CRC) is a complex and multi-factorial disease caused by the interaction of environmental and genetic predisposition factors. However the genetic susceptibility or predisposition risk of a certain individual to development of sporadic CRC remains largely undetermined. Recently chronic inflammation has been documented as a predisposing factor for CRC development. It was hypothesized that a pro-inflammatory genetic profile represented by genetic variation in inflammation response genes might be associated with increased susceptibility to CRC and a study was designed to test the hypothesis.