Screening For Small Molecule Inhibitors Of p27Kip1 Degradation

In a majority of human cancers, the cyclin-dependent kinase (CDK) inhibitor p27Kip1 is commonly found to be deregulated due to proteolysis by the ubiquitin-proteasome pathway involving the SCFSkp2 E3 ligase. Although proteasome inhibitors act to stabilize p27Kip1, small molecules agents inhibiting t...

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Bibliographic Details
Main Author:	Ooi, Li Ching
Format:	Thesis
Language:	English
Published:	2012
Subjects:	QH1 Natural history (General - Including nature conservation, geographical distribution)
Online Access:	http://eprints.usm.my/44880/
Abstract	Abstract here

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