Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates
Bioconjugates (PNIPAAm−graft−DNA) of poly(N-isopropylacrylamide) (PNIPAAm) grafted with single-stranded (ss) DNA were synthesized via radical copolymerization. The bioconjugates self-assembled above its lower critical solution temperature (LCST) in aqueous solution to form micelle-like colloidal nan...
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| フォーマット: | 学位論文 |
| 言語: | 英語 |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | http://eprints.usm.my/44882/ |
| _version_ | 1846216791487938560 |
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| author | Ooi, Wei Yang |
| author_facet | Ooi, Wei Yang |
| author_sort | Ooi, Wei Yang |
| description | Bioconjugates (PNIPAAm−graft−DNA) of poly(N-isopropylacrylamide) (PNIPAAm) grafted with single-stranded (ss) DNA were synthesized via radical copolymerization. The bioconjugates self-assembled above its lower critical solution temperature (LCST) in aqueous solution to form micelle-like colloidal nanoparticles. When the ssDNA of the nanoparticle hybridizes with complementary DNA, the particles aggregate above a certain threshold of salt concentration with drastically increased turbidity in solution. |
| first_indexed | 2025-10-17T08:25:36Z |
| format | Thesis |
| id | usm-44882 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-10-17T08:25:36Z |
| publishDate | 2012 |
| record_format | eprints |
| spelling | usm-448822019-07-05T02:18:22Z http://eprints.usm.my/44882/ Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates Ooi, Wei Yang QH1 Natural history (General - Including nature conservation, geographical distribution) Bioconjugates (PNIPAAm−graft−DNA) of poly(N-isopropylacrylamide) (PNIPAAm) grafted with single-stranded (ss) DNA were synthesized via radical copolymerization. The bioconjugates self-assembled above its lower critical solution temperature (LCST) in aqueous solution to form micelle-like colloidal nanoparticles. When the ssDNA of the nanoparticle hybridizes with complementary DNA, the particles aggregate above a certain threshold of salt concentration with drastically increased turbidity in solution. 2012-07 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44882/1/OOI%20WEI%20YANG.pdf Ooi, Wei Yang (2012) Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | QH1 Natural history (General - Including nature conservation, geographical distribution) Ooi, Wei Yang Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates |
| title | Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates |
| title_full | Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates |
| title_fullStr | Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates |
| title_full_unstemmed | Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates |
| title_short | Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates |
| title_sort | synthesis and characterization of thermoresponsive poly n isoproylacrylamide dna bioconjugates |
| topic | QH1 Natural history (General - Including nature conservation, geographical distribution) |
| url | http://eprints.usm.my/44882/ |
| work_keys_str_mv | AT ooiweiyang synthesisandcharacterizationofthermoresponsivepolynisoproylacrylamidednabioconjugates |