Functional Characterization Of Styr-3 Non-Protein-Coding Rna (npcRNA) In Salmonella enterica serovar Typhi
Non-protein-coding RNAs (npcRNAs) are RNA molecules that do not encode for proteins but are involved in modulating a myriad of cell regulatory processes, including bacterial drug resistance mechanisms. In this study, a novel npcRNA, StyR-3; discovered from the genome of S. Typhi was selected for fur...
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| Format: | Thèse |
| Langue: | anglais |
| Publié: |
2014
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| Accès en ligne: | http://eprints.usm.my/45075/ |
| Résumé: | Non-protein-coding RNAs (npcRNAs) are RNA molecules that do not encode for proteins but are involved in modulating a myriad of cell regulatory processes, including bacterial drug resistance mechanisms. In this study, a novel npcRNA, StyR-3; discovered from the genome of S. Typhi was selected for further characterization via bioinformatics and experimental-based approaches. This 144-nt intergenic npcRNA is located in the ramRA regulon of S. Typhi Ty2. The bioinformatics-based characterization showed that it is highly conserved among Salmonella species; besides having a stable secondary structure as was predicted by
LocaRNA software. |
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