The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
In this study, glioblastoma inhibition was acheived via the disruption of IL17A, which blocks angiogenesis using new derivatives of rosmarinic acid (RA). Anti-GBM activity of the compounds were determined through cell migration and cell proliferation assays with U87 MG, DBTRG MG, and EA.hy 926 cells...
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| Format: | Thèse |
| Langue: | anglais |
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2017
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| Accès en ligne: | http://eprints.usm.my/47701/ |
| Abstract | Abstract here |
| _version_ | 1855629958427181056 |
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| author | Khan, Md Shamsuddin Sultan |
| author_facet | Khan, Md Shamsuddin Sultan |
| author_sort | Khan, Md Shamsuddin Sultan |
| description | In this study, glioblastoma inhibition was acheived via the disruption of IL17A, which blocks angiogenesis using new derivatives of rosmarinic acid (RA). Anti-GBM activity of the compounds were determined through cell migration and cell proliferation assays with U87 MG, DBTRG MG, and EA.hy 926 cells. Antiangiogenic activity was investigated with tube formation, CAM, and aortic explant assays. The compounds’ activity in IL17A and VEGF expression was determined using ELISA and their apoptotic activity was assessed by the Caspase assay. The cancer pathway was determined using the reporter gene assay. |
| first_indexed | 2025-10-17T08:32:46Z |
| format | Thesis |
| id | usm-47701 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-10-17T08:32:46Z |
| publishDate | 2017 |
| record_format | EPrints |
| record_pdf | Restricted |
| spelling | usm-477012020-10-22T08:34:47Z http://eprints.usm.my/47701/ The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways Khan, Md Shamsuddin Sultan RS1-441 Pharmacy and materia medica In this study, glioblastoma inhibition was acheived via the disruption of IL17A, which blocks angiogenesis using new derivatives of rosmarinic acid (RA). Anti-GBM activity of the compounds were determined through cell migration and cell proliferation assays with U87 MG, DBTRG MG, and EA.hy 926 cells. Antiangiogenic activity was investigated with tube formation, CAM, and aortic explant assays. The compounds’ activity in IL17A and VEGF expression was determined using ELISA and their apoptotic activity was assessed by the Caspase assay. The cancer pathway was determined using the reporter gene assay. 2017-09 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/47701/1/THE%20DEVELOPMENT%20OF%20ROSMARINIC%20ACID.pdf%20cut.pdf Khan, Md Shamsuddin Sultan (2017) The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Khan, Md Shamsuddin Sultan The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways |
| thesis_level | PhD |
| title | The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways |
| title_full | The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways |
| title_fullStr | The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways |
| title_full_unstemmed | The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways |
| title_short | The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways |
| title_sort | development of rosmarinic acid derivatives to target il17a in glioblastoma multiforme via angiogenic pathways |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/47701/ |
| work_keys_str_mv | AT khanmdshamsuddinsultan thedevelopmentofrosmarinicacidderivativestotargetil17ainglioblastomamultiformeviaangiogenicpathways AT khanmdshamsuddinsultan developmentofrosmarinicacidderivativestotargetil17ainglioblastomamultiformeviaangiogenicpathways |