Predicting Gentamicin Induced Nephrotoxicity Using Pharmacometabonomic Approach

Gentamicin has been one of the most widely used antibiotics. However, its nephrotoxicity is a major concern as it is filtered through the kidneys for excretion in the form of urine. However, early diagnosis is difficult and no reliable metabolites as biomarkers are currently available. Thus, in this...

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Main Author: Aziz, Fatimatuzzahra’ Abd.
Format: Thesis
Language:English
Published: 2019
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/48355/
Abstract Abstract here
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author Aziz, Fatimatuzzahra’ Abd.
author_facet Aziz, Fatimatuzzahra’ Abd.
author_sort Aziz, Fatimatuzzahra’ Abd.
description Gentamicin has been one of the most widely used antibiotics. However, its nephrotoxicity is a major concern as it is filtered through the kidneys for excretion in the form of urine. However, early diagnosis is difficult and no reliable metabolites as biomarkers are currently available. Thus, in this study, a pharmacometabonomic approach using nuclear magnetic resonance (NMR) spectroscopy to investigate the altered metabolic pattern in serum and urine samples prior to administration of gentamicin has been employed to develop a model to predict nephrotoxicity induced by gentamicin and to identify the metabolic biomarkers associated. The aim of this study is therefore to determine the potential of urine and serum metabolites in predicting gentamicin induced nephrotoxicity.
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spelling usm-483552021-02-18T08:01:33Z http://eprints.usm.my/48355/ Predicting Gentamicin Induced Nephrotoxicity Using Pharmacometabonomic Approach Aziz, Fatimatuzzahra’ Abd. RS1-441 Pharmacy and materia medica Gentamicin has been one of the most widely used antibiotics. However, its nephrotoxicity is a major concern as it is filtered through the kidneys for excretion in the form of urine. However, early diagnosis is difficult and no reliable metabolites as biomarkers are currently available. Thus, in this study, a pharmacometabonomic approach using nuclear magnetic resonance (NMR) spectroscopy to investigate the altered metabolic pattern in serum and urine samples prior to administration of gentamicin has been employed to develop a model to predict nephrotoxicity induced by gentamicin and to identify the metabolic biomarkers associated. The aim of this study is therefore to determine the potential of urine and serum metabolites in predicting gentamicin induced nephrotoxicity. 2019-03 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/48355/1/full%20version%2007032019%20%281%29.pdf%20cut.pdf Aziz, Fatimatuzzahra’ Abd. (2019) Predicting Gentamicin Induced Nephrotoxicity Using Pharmacometabonomic Approach. PhD thesis, Universiti Sains Malaysia.
spellingShingle RS1-441 Pharmacy and materia medica
Aziz, Fatimatuzzahra’ Abd.
Predicting Gentamicin Induced Nephrotoxicity Using Pharmacometabonomic Approach
title Predicting Gentamicin Induced Nephrotoxicity Using Pharmacometabonomic Approach
title_full Predicting Gentamicin Induced Nephrotoxicity Using Pharmacometabonomic Approach
title_fullStr Predicting Gentamicin Induced Nephrotoxicity Using Pharmacometabonomic Approach
title_full_unstemmed Predicting Gentamicin Induced Nephrotoxicity Using Pharmacometabonomic Approach
title_short Predicting Gentamicin Induced Nephrotoxicity Using Pharmacometabonomic Approach
title_sort predicting gentamicin induced nephrotoxicity using pharmacometabonomic approach
topic RS1-441 Pharmacy and materia medica
url http://eprints.usm.my/48355/
work_keys_str_mv AT azizfatimatuzzahraabd predictinggentamicininducednephrotoxicityusingpharmacometabonomicapproach

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