Rapid Sonochemically-Assisted Green Synthesis Of Highly Stable And Biocompatible Platinum Nanoparticles As Novel Contrast Agent For Computed Tomography

• Auteur principal: Jameel, Mahmood Subhi
• Format: Thèse
• Langue: anglais
• Publié: 2021
• Sujets: QC1 Physics (General)
• Accès en ligne: http://eprints.usm.my/51990/

Platinum nanoparticles (Pt NPs) have some intrinsic properties, including good resistance to corrosion, chemical attacks, high surface area to volume ratio and hold massive potential to be strong contenders for CT imaging contrast agent due to their advantages of high X-ray absorption. However, the synthesis methods of Pt NPs as a contrast agent for CT imaging require elaborate preparation, use of hazardous and expensive chemicals and modified Pt NPs using different chemical materials (inorganic and organic) to improve their stability and biocompatibility. Herein, a simple and facile plant-directed preparation of Pt NPs was achieved to improve the Hounsfield (HU) values for CT imaging. A highly-stable, biocompatible and ultrasmall Pt NPs with a mean core size of 5 ±1.5 nm was obtained through one step, one-pot, user-friendly, and straightforward method using Prosopis farcta fruits extract (P. farcta) as reducing agent and stabilizer using a sonochemical synthesis. A Vibra-Cell ultrasonic solid horn with a ½ inch tip size, 20 kHz frequency, 750 watts power output and 40% amplitude was used in the sonochemical synthesis of Pt NPs. The formation of amorphous or crystalline Pt NPs is attributed to the sonication's cavitation microbubbles' rapid heating/cooling cycles. The purity, uniformity and crystallinity of Pt NPs synthesized by the sonochemical method were better than those obtained from the conventional (reduction) method. The Pt NPs also exhibited smaller particle size with higher colloidal stability and uniform hydrodynamic size.