Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines

Hevea brasiliensis rubber latex dialysed C-serum supernatant (DCS) sub-fraction has been reported to possess potential anti-proliferation activities against specific human breast (MDA-MB-231) and liver (HepG2) cancer cell lines through autoschizis cell death pathway. Further investigations on DCS tr...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي: Yang, Kok Lee
التنسيق: أطروحة
اللغة:الإنجليزية
منشور في: 2021
الموضوعات:
QH1 Natural history (General - Including nature conservation, geographical distribution)
الوصول للمادة أونلاين:http://eprints.usm.my/53332/
Abstract Abstract here
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author Yang, Kok Lee
author_facet Yang, Kok Lee
author_sort Yang, Kok Lee
description Hevea brasiliensis rubber latex dialysed C-serum supernatant (DCS) sub-fraction has been reported to possess potential anti-proliferation activities against specific human breast (MDA-MB-231) and liver (HepG2) cancer cell lines through autoschizis cell death pathway. Further investigations on DCS treatment (concentrations ranged between 0 to 100 μg/mL) on anti-proliferative effect in this study have shown that IC50 of DCS was at 8.81 μg/mL and 22.12 μg/mL for DBTRG (human brain glioblastoma) and MKN74 (human gastric tubular adenocarcinoma), respectively. Although DCS showed specificity in cancer cell lines based on cell viability assays, its genotoxicity effects are important in view of its employment in human subjects if it would be developed into an anti-cancer drug.
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spelling usm-533322022-07-13T02:04:26Z http://eprints.usm.my/53332/ Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines Yang, Kok Lee QH1 Natural history (General - Including nature conservation, geographical distribution) Hevea brasiliensis rubber latex dialysed C-serum supernatant (DCS) sub-fraction has been reported to possess potential anti-proliferation activities against specific human breast (MDA-MB-231) and liver (HepG2) cancer cell lines through autoschizis cell death pathway. Further investigations on DCS treatment (concentrations ranged between 0 to 100 μg/mL) on anti-proliferative effect in this study have shown that IC50 of DCS was at 8.81 μg/mL and 22.12 μg/mL for DBTRG (human brain glioblastoma) and MKN74 (human gastric tubular adenocarcinoma), respectively. Although DCS showed specificity in cancer cell lines based on cell viability assays, its genotoxicity effects are important in view of its employment in human subjects if it would be developed into an anti-cancer drug. 2021-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/53332/1/YANG%20KOK%20LEE%20-%20TESIS.pdf%20cut.pdf Yang, Kok Lee (2021) Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines. PhD thesis, Universiti Sains Malaysia.
spellingShingle QH1 Natural history (General - Including nature conservation, geographical distribution)
Yang, Kok Lee
Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines
thesis_level PhD
title Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines
title_full Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines
title_fullStr Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines
title_full_unstemmed Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines
title_short Single Agent And Synergistic Activity Of Latex C-Serum With Led Red Light In Cancer Cell Lines
title_sort single agent and synergistic activity of latex c serum with led red light in cancer cell lines
topic QH1 Natural history (General - Including nature conservation, geographical distribution)
url http://eprints.usm.my/53332/
work_keys_str_mv AT yangkoklee singleagentandsynergisticactivityoflatexcserumwithledredlightincancercelllines

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