Characterisation of beta globin gene cluster deletions using multiplex-Gap-PCR and Multiplex Ligation-dependent Probe Amplification (MLPA)

Deletions in the beta (β)-globin gene cluster are usually rare, yet this type of mutation is problematic to detect, and subsequently possess a challenge in the diagnostic laboratory. Deletions in this cluster are usually related to the heterozygous of the delta beta thalassaemia (δβ-thalassaemia)...

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