The Effects Of Mitragynine On P-Glycoprotein Regulations And Its Neurotoxicity Mechanisms In Brain Cell Lines

The main objective is to determine the effects of mitragynine on P-gp regulations and neurotoxicity effects of drug-herb interactions between mitragynine and P-gp substrates in the PC12 cells using both in silico and in vitro approaches.

Bibliographic Details
Main Author:	Abduraman, Muhammad Asyraf
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/59299/
Abstract	Abstract here

Similar Items

Synthesis, Characterization And Analgesic Activity Of Mitragynine Analogues
by: Ramlee, Nurul Izzati
Published: (2015)

Investigation Of In Vitro Permeation Of Mitragynine Through The Skin
by: Sim, Yee Shan
Published: (2023)

The Effect Of Mitragynine On Cyclic Amp Formation And Mrna Expression Of Mu-Opioid Receptors Mediated By Chronic Morphine Treatment In Sk-N-Sh Neuroblastoma Cell
by: Jamil, Mohd Fadzly Amar
Published: (2013)

Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats
by: Yusoff, Nurul Hasnida Mohammad
Published: (2018)

Cytotoxicity And Cell Deatl-I Mechanisms Of Epipremnum Pinna Tum (L.) Engl. Extracts In T-47d, A Breast Carcinoma Cell Line
by: Tan, Mei Lan
Published: (2003)

Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein
by: Kong, Mei Suen
Published: (2017)

Synthesis Of Blood-Brain Barrier Permeable Aurones As Modulators Of Microglia
by: Chia, Shi Yi
Published: (2023)

Potential Of Stichopus horrens And Stichopus vastus Extracts As Anticancer And Wound Healing Agents: Effects On Breast Cancer And Fibroblast Cell Lines
by: Azemi, Nurul Adila
Published: (2014)

Changes In Central And Peripheral Regulation Of Streptozotocin-Induced Diabetic Rats
by: Hassan, Zurina
Published: (2012)

Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
by: Al-Amin, Md
Published: (2021)

Effects Of Atrial Natriuretic Peptide And Pregnancy On The Central And Peripheral Regulation Of The Cardiovascular Functions
by: Yusoff, Nurul Hasnida Mohammad
Published: (2010)

Evaluation Of The Hepatoprotective Effects Of Tocotrienols An The Relationship Between Non-Alcoholic Fatty Liver And Brain White-Matter Lesions
by: Magosso, Enrico
Published: (2011)

Synthesis And Characterization Of pH-Sensitive Polyelectrolyte Nanogels For Oral Delivery Of Bovine Serum Albumin And Insulin As Model Proteins
by: Mudassir, Jahanzeb
Published: (2018)

Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action
by: Varghese, Christapher Parayil
Published: (2017)

Health-Related Quality Of Life Of Patients With Unresectable Hepatocellular Carcinoma And Costeffectiveness Of The First-Line Treatments In A Medical University Hospital In Yunnan, China
by: Gong, Hongyu
Published: (2024)

Pharmaceutical Drug Pricing In Malaysia: An Assessment Of Perception, Mechanisms, And International Comparisons
by: Shukeri, Mohammad Amirul Ashraf Mohammad
Published: (2023)

Development Of Nano-Formulation Using Pvp/P407 Based On Solid Dispersion From Standardised Ethanolic Extract Of Orthosiphon Stamineus Leaf For Solubility And Oral Bioavailability Improvements
by: Saidan, Noor Hafizoh
Published: (2017)

Antihyperlipidaemic And Antioxidant Activities Of Extracts Of Different Parts Of Averrhoa Carambola And Elucidation Of Their Mechanisms Of Action
by: Sultan Ayesh, Mohammed Saghir
Published: (2015)

Peripheral Antihypertensive Mechanisms Of Zing/Ber Officinale Var. Rubrumin Spontaneously Hypertensive Rats
by: Razali, Nadiah
Published: (2022)

Elucidation Of The Molecular Mechanisms Of Orthosiphon Aristatus Extract In Non-Alcoholic Fatty Liver Disease
by: Al Shehade, Salah Abd Alrazak
Published: (2023)

Effect Of Root Extracts Of Eurycoma Longifolia Jack On Rabbit Penile Erection And Underlying Mechanism Of Action
by: Wizneh, Faramarz Majidi
Published: (2016)

Study On Traditional Medicine-modern Drug Interaction And Its Molecular Mechanism Elucidation In Rat Liver
by: A. Taher, Yousef
Published: (1998)

Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action
by: Tri, Widyawati
Published: (2015)

Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action
by: Widyawati, Tri
Published: (2015)

Investigation Of Molecular Mechanisms Underlying The Anti-Tumor And Anti-Angiogenic Activities Of Orthosiphon Stamineus Towards Colorectal Cancer
by: Al-Suede, Fouad Saleih Resq
Published: (2016)

Linezolid Susceptibility And Potential Resistance Mechanisms Among Mrsa Isolated From Two Major Public Hospitals In Malaysia
by: Thiruchelvi , Pulingam
Published: (2014)

Discovery Of New Targeting Agents Against Gapdh Receptor: In Silico And In Vitro Studies
by: Noh, Muhammad Amirul Asyraf
Published: (2023)

Development Of An Animal Model To Recover Poly(3-Hydroxybutyrate) Granules From Dried Cells Of Cupriavidus Necator H16
by: Balakrishnan, Kunasundari
Published: (2013)

The Effects Of A Synbiotic Product On The Blood Lipid Prof,Ile And Red Blood Cell Morphology Among Hypercholesterolemic Subjects
by: Ooi , Lay Gaik
Published: (2010)

Effect Of Standardised Methanolic Extract Of Phyllanthus Niruri (Linn.) On Phase I And II Drug Metabolism And Its Molecular Mechanism Elucidation In Rat Liver
by: Bashir, Moath Kahtan
Published: (2010)

Effects Of Obesity On The Risk Of Mechanical Ventilation, Mortality, Survival Rate And Post Covid-19 Symptoms Among Hospitalized Covid-19 Patients At Tertiary Care Hospitals Of Hyderabad And Karachi, Pakistan
by: Qureshi, Ali
Published: (2024)

Clinical Outcomes Of Induction TherapyWith Addition Of High Dose Methotrexate And Cytarabine To Existing Standard Treatment In Patients With Newly Diagnosed Diffused Large B-Cell Lymphoma: A Retrospective Study
by: Dang, Chee Chean
Published: (2018)

Differentiation and proliferation activities of human foetal osteoblast cell line (hFOB 1.19) treated with a polyphenol, tannic acid alone or in combination with pamidronate
by: Hashim, Nor Munira
Published: (2018)

Documentation, antimycobacterial activity, and phytochemical profiling of selected medicinal plants used by the jakun community in Johor
by: Sabran, Siti Fatimah
Published: (2016)

One-Year Survival And Performance Status In Adult Patients With Sepsis, Severe Sepsis, And Septic Shock
by: Alkhalaf, Mustafa Salman M.
Published: (2013)

Assessment Of Polychlorinated Dioxins/Furans In Ambient Air And Soil Samples From Selected Industrial Sites Using Palm Kernel Shell Activated Carbon In A Modified Sample Preparation Method
by: Ahmad, Abdul Rahim
Published: (2012)

Prediction Of Uncontrolled Dyslipidemia Of Cardiac Outpatients And The Adverse Effect Of Pharmaceutical Excipients
by: Abdulrazzaq, Hadeer Akram
Published: (2013)

The Prevalence And Risk Factors Of Cognitive Dysfunction In Patients With Diabetes Mellitus In Iraq
by: Najim, Hafsa S.
Published: (2013)

Antihyperglycemic And Toxicological Studies Of Ethanolic–Aqueous Extracts Of Gynura Procumbens
by: Algariri, Khaled Saleh
Published: (2013)

In Vitro Anticancer Activity Guided Investigation Of The Phytochemicals Of Typhonium Flagelliforme (Lodd.) Blume (Araceae)
by: Lai , Choon Sheen
Published: (2010)