Phytochemical, Bioassay And In Silico Studies On Anti - Cholinesterase Activities Of Cassia Timoriensis Dc. And Cassia Grandis L.F.
Historically, Cassia species have been demonstrated to possess several biological activities. However, scientific research on Cassia timoriensis and Cassia grandis remains limited. In this study, the aim was to discover new cholinesterase (ChE) inhibitors to alleviate acetylcholine (ACh) depletion i...
| 第一著者: | |
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| フォーマット: | 学位論文 |
| 言語: | 英語 |
| 出版事項: |
2022
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| 主題: | |
| オンライン･アクセス: | http://eprints.usm.my/59710/ |
| Abstract | Abstract here |
| _version_ | 1855630312981135360 |
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| author | Al-Hawarri, Maram Basem Tawfiq |
| author_facet | Al-Hawarri, Maram Basem Tawfiq |
| author_sort | Al-Hawarri, Maram Basem Tawfiq |
| description | Historically, Cassia species have been demonstrated to possess several biological activities. However, scientific research on Cassia timoriensis and Cassia grandis remains limited. In this study, the aim was to discover new cholinesterase (ChE) inhibitors to alleviate acetylcholine (ACh) depletion in Alzheimer’s disease (AD). Hence, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory potentials, radical scavenging ability, and anti-inflammatory properties of various extracts of C. timoriensis and C. grandis were carried out using Ellman’s assay, DPPH assay, and an albumin denaturation assay, respectively. |
| first_indexed | 2025-10-17T08:46:58Z |
| format | Thesis |
| id | usm-59710 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-10-17T08:46:58Z |
| publishDate | 2022 |
| record_format | EPrints |
| record_pdf | Restricted |
| spelling | usm-597102023-12-20T02:17:57Z http://eprints.usm.my/59710/ Phytochemical, Bioassay And In Silico Studies On Anti - Cholinesterase Activities Of Cassia Timoriensis Dc. And Cassia Grandis L.F. Al-Hawarri, Maram Basem Tawfiq RS1-441 Pharmacy and materia medica Historically, Cassia species have been demonstrated to possess several biological activities. However, scientific research on Cassia timoriensis and Cassia grandis remains limited. In this study, the aim was to discover new cholinesterase (ChE) inhibitors to alleviate acetylcholine (ACh) depletion in Alzheimer’s disease (AD). Hence, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory potentials, radical scavenging ability, and anti-inflammatory properties of various extracts of C. timoriensis and C. grandis were carried out using Ellman’s assay, DPPH assay, and an albumin denaturation assay, respectively. 2022-09 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/59710/1/24%20Pages%20from%20MARAM%20BASEM%20TAWFIQ%20AL-HAWARRI%20-%20TESIS.pdf Al-Hawarri, Maram Basem Tawfiq (2022) Phytochemical, Bioassay And In Silico Studies On Anti - Cholinesterase Activities Of Cassia Timoriensis Dc. And Cassia Grandis L.F. PhD thesis, Perpustakaan Hamzah Sendut. |
| spellingShingle | RS1-441 Pharmacy and materia medica Al-Hawarri, Maram Basem Tawfiq Phytochemical, Bioassay And In Silico Studies On Anti - Cholinesterase Activities Of Cassia Timoriensis Dc. And Cassia Grandis L.F. |
| thesis_level | PhD |
| title | Phytochemical, Bioassay And In Silico Studies On Anti - Cholinesterase Activities Of Cassia Timoriensis Dc. And Cassia Grandis L.F. |
| title_full | Phytochemical, Bioassay And In Silico Studies On Anti - Cholinesterase Activities Of Cassia Timoriensis Dc. And Cassia Grandis L.F. |
| title_fullStr | Phytochemical, Bioassay And In Silico Studies On Anti - Cholinesterase Activities Of Cassia Timoriensis Dc. And Cassia Grandis L.F. |
| title_full_unstemmed | Phytochemical, Bioassay And In Silico Studies On Anti - Cholinesterase Activities Of Cassia Timoriensis Dc. And Cassia Grandis L.F. |
| title_short | Phytochemical, Bioassay And In Silico Studies On Anti - Cholinesterase Activities Of Cassia Timoriensis Dc. And Cassia Grandis L.F. |
| title_sort | phytochemical bioassay and in silico studies on anti cholinesterase activities of cassia timoriensis dc and cassia grandis l f |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/59710/ |
| work_keys_str_mv | AT alhawarrimarambasemtawfiq phytochemicalbioassayandinsilicostudiesonanticholinesteraseactivitiesofcassiatimoriensisdcandcassiagrandislf |