Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents
A total of eleven ortho-carboxamido stilbenes (50a-50k) in 63-83 % yield have been synthesized using our modified Heck coupling method, and characterized using FT-IR, NMR, and HRMS. The research started with the Wittig reaction of 3,5-dimethoxybenzaldehyde (45) and methyltriphenylphosphonium iodide...
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| Format: | Thesis |
| Language: | English |
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2022
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| Online Access: | http://eprints.usm.my/59726/ |
| Abstract | Abstract here |
| _version_ | 1855633022004494336 |
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| author | Mohamad, Norhadi |
| author_facet | Mohamad, Norhadi |
| author_sort | Mohamad, Norhadi |
| description | A total of eleven ortho-carboxamido stilbenes (50a-50k) in 63-83 % yield have been synthesized using our modified Heck coupling method, and characterized using FT-IR, NMR, and HRMS. The research started with the Wittig reaction of 3,5-dimethoxybenzaldehyde (45) and methyltriphenylphosphonium iodide to form 3,5-dimethoxystyrene (46) followed by the Heck reaction with amide derivatives (49) under basic conditions to provide the corresponding (E)-stilbene derivatives (50a-50k). Five ortho-carboxamido stilbenes (50a-50e) were subjected to anti-diabetic studies on α-amylase and α-glucosidase enzymes. |
| first_indexed | 2025-10-17T08:47:02Z |
| format | Thesis |
| id | usm-59726 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-10-17T08:47:02Z |
| publishDate | 2022 |
| record_format | EPrints |
| record_pdf | Restricted |
| spelling | usm-597262024-01-02T03:28:42Z http://eprints.usm.my/59726/ Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents Mohamad, Norhadi QD1-999 Chemistry A total of eleven ortho-carboxamido stilbenes (50a-50k) in 63-83 % yield have been synthesized using our modified Heck coupling method, and characterized using FT-IR, NMR, and HRMS. The research started with the Wittig reaction of 3,5-dimethoxybenzaldehyde (45) and methyltriphenylphosphonium iodide to form 3,5-dimethoxystyrene (46) followed by the Heck reaction with amide derivatives (49) under basic conditions to provide the corresponding (E)-stilbene derivatives (50a-50k). Five ortho-carboxamido stilbenes (50a-50e) were subjected to anti-diabetic studies on α-amylase and α-glucosidase enzymes. 2022-09 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/59726/1/Pages%20from%20NORHADI%20BIN%20MOHAMAD%20-%20TESIS%20cut.pdf Mohamad, Norhadi (2022) Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | QD1-999 Chemistry Mohamad, Norhadi Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents |
| thesis_level | Master |
| title | Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents |
| title_full | Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents |
| title_fullStr | Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents |
| title_full_unstemmed | Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents |
| title_short | Design, Synthesis, Biological Evaluation, And Molecular Docking Studies Of Ortho-Carboxamido Stilbenes As Anti-Diabetic And Anti-Proliferative Agents |
| title_sort | design synthesis biological evaluation and molecular docking studies of ortho carboxamido stilbenes as anti diabetic and anti proliferative agents |
| topic | QD1-999 Chemistry |
| url | http://eprints.usm.my/59726/ |
| work_keys_str_mv | AT mohamadnorhadi designsynthesisbiologicalevaluationandmoleculardockingstudiesoforthocarboxamidostilbenesasantidiabeticandantiproliferativeagents |