Molecular analysis of the promoter and the core promoter region Of the smn2 gene in circumscribing the clinical severity of sma

Spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by the absence of the full length SMN protein (FL-SMN) as a result of mutation or deletion of SMN\ gene. The isoform to this gene, SMN2, with mutation in 1 base pair, encodes for 10% of FL-SMN protein and is reported to decrease...

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