Effect of 12 hours overnight fasting on brain perfusion using TC-99M ETHYL cysteinate dimer Spect/Ct with scenium analysis in smokers

• Main Author: Norsan, Nor Maslina Mohamad
• Format: Thesis
• Language: English
• Published: 2025
• Subjects: R Medicine; RA Public aspects of medicine
• Online Access: http://eprints.usm.my/62833/

Cigarette smoking is not only a common habit that occurs in Malaysia but also the whole world. This habit has been common among adults but nowadays teenagers are also addicted to smoking cigarettes. The destructive substances in cigarettes such as nicotine can reduce activity in limbic, posterior cingulate, prefrontal cortex and increase activity in their cuneus and precuneus. This study recruited subjects that are 18 years old and above and fulfill inclusion and exclusion criteria, smokers (n=18) from Klinik Rawatan Keluarga (KRK) and non-smokers (n=11) from volunteer poster. The brain perfusion between both groups was compared by using Single Photon Emission Computed Tomography-Computed Tomography (SPECT/CT) in Hospital Universiti Sains Malaysia (HUSM) by using technetium-99m-ethyl cysteinate dimer (99mTc-ECD) as a radiotracer for both fasting and non-fasting state and Scenium software was use for quantitative brain image interpretation. Smokers were categorized into mild (n=17), moderate (n=1) and severe smoker (n=0) based on level of addiction fagerstrom questionnaire. Thus, this study objectives were to determine brain perfusion between smoker and non-smoker, to compare the difference in brain perfusion among smoker between fasting and non-fasting state and to compare the difference in brain perfusion among non-smoker between fasting and non-fasting state. The result of Mann Whitney U test for the first objective shows that there is significant difference in left and right of superior frontal gyrus (SFG) dorsolateral and orbital. Wilcoxon Signed Rank test was used for second and third objective and there is significant difference in left amygdala among smoker and no significant difference in brain perfusion area observed among non-smokers after overnight fasting (12 hours fasting).