Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In Treating Alzheimer’s Disease
AD begins with memory and cognitive impairment and progresses to speech and movement skills which affects 35% of 80-year-olds adult. According to the amyloid cascade hypothesis, two proteins which are Amyloid Precursor Protein (APP), and Presenilin 1 (PS1) play a vital role in contributing to AD. Mu...
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| Format: | Thesis |
| Language: | English |
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2024
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| Online Access: | http://eprints.usm.my/62948/ |
| Abstract | Abstract here |
| _version_ | 1855633281970601984 |
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| author | Mohd Suhaimi, Ahmad Marwazi |
| author_facet | Mohd Suhaimi, Ahmad Marwazi |
| author_sort | Mohd Suhaimi, Ahmad Marwazi |
| description | AD begins with memory and cognitive impairment and progresses to speech and movement skills which affects 35% of 80-year-olds adult. According to the amyloid cascade hypothesis, two proteins which are Amyloid Precursor Protein (APP), and Presenilin 1 (PS1) play a vital role in contributing to AD. Mutated APP and PS1 are shown to be responsible for the production of pathogenic amyloid-beta (Aβ42) peptide in AD patient, which then forms Aβ42 plaques and deposited in the brain. Presenilin 1 (PS1) is the primary component of γ-secretase which catalyses the
cleavage of APP (neuron development) especially at the beta region of APP in both amyloid pathways. |
| first_indexed | 2025-10-17T08:54:48Z |
| format | Thesis |
| id | usm-62948 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-10-17T08:54:48Z |
| publishDate | 2024 |
| record_format | EPrints |
| record_pdf | Restricted |
| spelling | usm-629482025-10-13T08:07:48Z http://eprints.usm.my/62948/ Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In Treating Alzheimer’s Disease Mohd Suhaimi, Ahmad Marwazi RS1-441 Pharmacy and materia medica AD begins with memory and cognitive impairment and progresses to speech and movement skills which affects 35% of 80-year-olds adult. According to the amyloid cascade hypothesis, two proteins which are Amyloid Precursor Protein (APP), and Presenilin 1 (PS1) play a vital role in contributing to AD. Mutated APP and PS1 are shown to be responsible for the production of pathogenic amyloid-beta (Aβ42) peptide in AD patient, which then forms Aβ42 plaques and deposited in the brain. Presenilin 1 (PS1) is the primary component of γ-secretase which catalyses the cleavage of APP (neuron development) especially at the beta region of APP in both amyloid pathways. 2024-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/62948/1/Pages%20from%20AHMAD%20MARWAZI%20BIN%20MOHD%20SUHAIMI%20-%20TESIS.pdf Mohd Suhaimi, Ahmad Marwazi (2024) Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In Treating Alzheimer’s Disease. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Mohd Suhaimi, Ahmad Marwazi Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In Treating Alzheimer’s Disease |
| thesis_level | Master |
| title | Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In
Treating Alzheimer’s Disease |
| title_full | Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In
Treating Alzheimer’s Disease |
| title_fullStr | Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In
Treating Alzheimer’s Disease |
| title_full_unstemmed | Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In
Treating Alzheimer’s Disease |
| title_short | Computational Elucidation Of Binding Interactions For Thicapa And Poet On Amyloid Beta 42 And Presenilin 1 In
Treating Alzheimer’s Disease |
| title_sort | computational elucidation of binding interactions for thicapa and poet on amyloid beta 42 and presenilin 1 in treating alzheimer s disease |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/62948/ |
| work_keys_str_mv | AT mohdsuhaimiahmadmarwazi computationalelucidationofbindinginteractionsforthicapaandpoetonamyloidbeta42andpresenilin1intreatingalzheimersdisease |