The Effect Of Mitragynine Addiction In Rats On Histone Regulations And Neuroplasticity
Mitragynine (MIT) was reported to develop addiction and impair cognitive functions. In acute studies, MIT was found to disrupt hippocampal synaptic transmission and distort memory via unknown mechanisms. This project evaluated the impact of 14 days of MIT exposure on the modulation of histone, synap...
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| フォーマット: | 学位論文 |
| 言語: | 英語 |
| 出版事項: |
2024
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| 主題: | |
| オンライン･アクセス: | http://eprints.usm.my/62995/ |
| _version_ | 1846218635460214784 |
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| author | Suleiman, Yunusa |
| author_facet | Suleiman, Yunusa |
| author_sort | Suleiman, Yunusa |
| description | Mitragynine (MIT) was reported to develop addiction and impair cognitive functions. In acute studies, MIT was found to disrupt hippocampal synaptic transmission and distort memory via unknown mechanisms. This project evaluated the impact of 14 days of MIT exposure on the modulation of histone, synaptic transmission, and its potential mechanisms as well as dopaminergic, GABAergic, cholinergic, and glutamatergic systems in the rats’ brains. The impact of pharmacological inhibition of histone deacetylase enzyme on MIT action was also evaluated. |
| first_indexed | 2025-10-17T08:54:55Z |
| format | Thesis |
| id | usm-62995 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-10-17T08:54:55Z |
| publishDate | 2024 |
| record_format | eprints |
| spelling | usm-629952025-10-16T03:00:06Z http://eprints.usm.my/62995/ The Effect Of Mitragynine Addiction In Rats On Histone Regulations And Neuroplasticity Suleiman, Yunusa RM300-666 Drugs and their actions Mitragynine (MIT) was reported to develop addiction and impair cognitive functions. In acute studies, MIT was found to disrupt hippocampal synaptic transmission and distort memory via unknown mechanisms. This project evaluated the impact of 14 days of MIT exposure on the modulation of histone, synaptic transmission, and its potential mechanisms as well as dopaminergic, GABAergic, cholinergic, and glutamatergic systems in the rats’ brains. The impact of pharmacological inhibition of histone deacetylase enzyme on MIT action was also evaluated. 2024-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/62995/1/Pages%20from%20YUNUSA%20SULEIMAN%20-%20TESIS.pdf Suleiman, Yunusa (2024) The Effect Of Mitragynine Addiction In Rats On Histone Regulations And Neuroplasticity. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RM300-666 Drugs and their actions Suleiman, Yunusa The Effect Of Mitragynine Addiction In Rats On Histone Regulations And Neuroplasticity |
| title | The Effect Of Mitragynine Addiction In Rats On Histone Regulations And Neuroplasticity |
| title_full | The Effect Of Mitragynine Addiction In Rats On Histone Regulations And Neuroplasticity |
| title_fullStr | The Effect Of Mitragynine Addiction In Rats On Histone Regulations And Neuroplasticity |
| title_full_unstemmed | The Effect Of Mitragynine Addiction In Rats On Histone Regulations And Neuroplasticity |
| title_short | The Effect Of Mitragynine Addiction In Rats On Histone Regulations And Neuroplasticity |
| title_sort | effect of mitragynine addiction in rats on histone regulations and neuroplasticity |
| topic | RM300-666 Drugs and their actions |
| url | http://eprints.usm.my/62995/ |
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