Immunogenicity Evaluation Of A133 And Ss-Ir: Development Of Vaccine Candidates Against Strongyloides Stercoralis
Strongyloidiasis, caused by the nematode Strongyloides stercoralis, remains a threat to global public health. To date, a vaccine against strongyloidiasis remains unavailable and there was no significant development in this area after discovering the potential of recombinant protein Ss-IR as a vaccin...
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| Format: | Thesis |
| Language: | English |
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2024
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| Online Access: | http://eprints.usm.my/63148/ |
| Abstract | Abstract here |
| _version_ | 1855630889991536640 |
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| author | Wong, Matthew Tze Jian |
| author_facet | Wong, Matthew Tze Jian |
| author_sort | Wong, Matthew Tze Jian |
| description | Strongyloidiasis, caused by the nematode Strongyloides stercoralis, remains a threat to global public health. To date, a vaccine against strongyloidiasis remains unavailable and there was no significant development in this area after discovering the potential of recombinant protein Ss-IR as a vaccine candidate in 2011. In light of recent developments in the diagnosis of strongyloidiasis, A133 emerged in 2021 as an excellent diagnostic antigen, prompting curiosity for its potential as a vaccine candidate. Therefore, this study aimed to evaluate the efficacy of recombinant protein A133 in comparison to Ss-IR, as a potential vaccine candidate against S. stercoralis by investigating humoral and cellular immune responses in immunised mice. |
| first_indexed | 2025-12-24T00:13:41Z |
| format | Thesis |
| id | usm-63148 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-12-24T00:13:41Z |
| publishDate | 2024 |
| record_format | EPrints |
| record_pdf | Restricted |
| spelling | usm-631482025-10-30T08:03:58Z http://eprints.usm.my/63148/ Immunogenicity Evaluation Of A133 And Ss-Ir: Development Of Vaccine Candidates Against Strongyloides Stercoralis Wong, Matthew Tze Jian R5-920 Medicine (General) Strongyloidiasis, caused by the nematode Strongyloides stercoralis, remains a threat to global public health. To date, a vaccine against strongyloidiasis remains unavailable and there was no significant development in this area after discovering the potential of recombinant protein Ss-IR as a vaccine candidate in 2011. In light of recent developments in the diagnosis of strongyloidiasis, A133 emerged in 2021 as an excellent diagnostic antigen, prompting curiosity for its potential as a vaccine candidate. Therefore, this study aimed to evaluate the efficacy of recombinant protein A133 in comparison to Ss-IR, as a potential vaccine candidate against S. stercoralis by investigating humoral and cellular immune responses in immunised mice. 2024-02 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/63148/1/Pages%20from%20MATTHEW%20WONG%20TZE%20JIAN%20-%20TESIS.pdf Wong, Matthew Tze Jian (2024) Immunogenicity Evaluation Of A133 And Ss-Ir: Development Of Vaccine Candidates Against Strongyloides Stercoralis. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | R5-920 Medicine (General) Wong, Matthew Tze Jian Immunogenicity Evaluation Of A133 And Ss-Ir: Development Of Vaccine Candidates Against Strongyloides Stercoralis |
| thesis_level | PhD |
| title | Immunogenicity Evaluation Of A133 And Ss-Ir: Development Of Vaccine Candidates Against Strongyloides Stercoralis |
| title_full | Immunogenicity Evaluation Of A133 And Ss-Ir: Development Of Vaccine Candidates Against Strongyloides Stercoralis |
| title_fullStr | Immunogenicity Evaluation Of A133 And Ss-Ir: Development Of Vaccine Candidates Against Strongyloides Stercoralis |
| title_full_unstemmed | Immunogenicity Evaluation Of A133 And Ss-Ir: Development Of Vaccine Candidates Against Strongyloides Stercoralis |
| title_short | Immunogenicity Evaluation Of A133 And Ss-Ir: Development Of Vaccine Candidates Against Strongyloides Stercoralis |
| title_sort | immunogenicity evaluation of a133 and ss ir development of vaccine candidates against strongyloides stercoralis |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/63148/ |
| work_keys_str_mv | AT wongmatthewtzejian immunogenicityevaluationofa133andssirdevelopmentofvaccinecandidatesagainststrongyloidesstercoralis |