Design, Synthesis And Biological Evaluation Of New Opioid Analgesics Based On Tetrahydro-Β-Carboline Scaffold In Zebrafish (Danio Rerio) Larvae
The present study aims to design, synthesise, and evaluate the analgesic activities of THβC derivatives. A database of 25,227 THβC analogues was prepared from structure based virtual screening of the ZINC database for bromine fragments and linking the fragments at the N2 position of the THβC scaffol...
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| Format: | Thesis |
| Language: | English |
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2024
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| Online Access: | http://eprints.usm.my/63170/ |
| Abstract | Abstract here |
| _version_ | 1861713198826127360 |
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| author | Alananzeh, Waleed Abdullah Ahmad |
| author_facet | Alananzeh, Waleed Abdullah Ahmad |
| author_sort | Alananzeh, Waleed Abdullah Ahmad |
| description | The present study aims to design, synthesise, and evaluate the analgesic activities of THβC derivatives. A database of 25,227 THβC analogues was prepared from structure based virtual screening of the ZINC database for bromine fragments and linking the fragments at the N2 position of the THβC scaffold. |
| first_indexed | 2025-12-24T00:13:47Z |
| format | Thesis |
| id | usm-63170 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-12-24T00:13:47Z |
| publishDate | 2024 |
| record_format | EPrints |
| record_pdf | Restricted |
| spelling | usm-631702025-11-04T08:15:07Z http://eprints.usm.my/63170/ Design, Synthesis And Biological Evaluation Of New Opioid Analgesics Based On Tetrahydro-Β-Carboline Scaffold In Zebrafish (Danio Rerio) Larvae Alananzeh, Waleed Abdullah Ahmad RM300-666 Drugs and their actions The present study aims to design, synthesise, and evaluate the analgesic activities of THβC derivatives. A database of 25,227 THβC analogues was prepared from structure based virtual screening of the ZINC database for bromine fragments and linking the fragments at the N2 position of the THβC scaffold. 2024-03 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/63170/1/Pages%20from%20WALEED%20ABDULLAH%20AHMAD%20ALANANZEH%20-%20TESIS.pdf Alananzeh, Waleed Abdullah Ahmad (2024) Design, Synthesis And Biological Evaluation Of New Opioid Analgesics Based On Tetrahydro-Β-Carboline Scaffold In Zebrafish (Danio Rerio) Larvae. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RM300-666 Drugs and their actions Alananzeh, Waleed Abdullah Ahmad Design, Synthesis And Biological Evaluation Of New Opioid Analgesics Based On Tetrahydro-Β-Carboline Scaffold In Zebrafish (Danio Rerio) Larvae |
| thesis_level | PhD |
| title | Design, Synthesis And Biological Evaluation Of New Opioid Analgesics Based On Tetrahydro-Β-Carboline Scaffold In Zebrafish (Danio Rerio) Larvae |
| title_full | Design, Synthesis And Biological Evaluation Of New Opioid Analgesics Based On Tetrahydro-Β-Carboline Scaffold In Zebrafish (Danio Rerio) Larvae |
| title_fullStr | Design, Synthesis And Biological Evaluation Of New Opioid Analgesics Based On Tetrahydro-Β-Carboline Scaffold In Zebrafish (Danio Rerio) Larvae |
| title_full_unstemmed | Design, Synthesis And Biological Evaluation Of New Opioid Analgesics Based On Tetrahydro-Β-Carboline Scaffold In Zebrafish (Danio Rerio) Larvae |
| title_short | Design, Synthesis And Biological Evaluation Of New Opioid Analgesics Based On Tetrahydro-Β-Carboline Scaffold In Zebrafish (Danio Rerio) Larvae |
| title_sort | design synthesis and biological evaluation of new opioid analgesics based on tetrahydro β carboline scaffold in zebrafish danio rerio larvae |
| topic | RM300-666 Drugs and their actions |
| url | http://eprints.usm.my/63170/ |
| work_keys_str_mv | AT alananzehwaleedabdullahahmad designsynthesisandbiologicalevaluationofnewopioidanalgesicsbasedontetrahydrobcarbolinescaffoldinzebrafishdanioreriolarvae |