| Summary: | Non-Hodgkin's lymphoma (NHL) is ranked twelfth among all
cancers world-wide, in which it is more prevalent in males compared to
females.
The aim of the present study was to determine the presence and
distribution of Epstein-Barr virus (EBV) in non-Hodgkin's lymphomas
(NHL) of the gastrointestinal tract (GIT) tissue samples obtained from 25
Malaysian patients diagnosed clinically and histopathologically. The
gastrointestinal lymphomas analysed in the present study was divided into
NHL of the ileocecal (9 cases), NHL of the small intestine (7 cases), NHL
of the stomach (5 cases), NHL of the abdomen (1 case), NHL of the
wedge ulcer (1 case), NHL of rectum fotic (1 case) and finally NHL of the
hemicolon (1 case). The presence of EBV in all of the above mentioned
tissue samples, after formalin fixation and paraffin embedding was carried
out by using conventional in situ hybridization technology.
Two out of 25 cases of NHL of the GIT analysed in the present
study, demonstrated positive signals for EBV/EBER. In the first positive
case, EBV/EBER signals were located in transformed lymphocytes in the
serosa layer of the small intestine (14.3%). In the second EBV positive case, EBV/EBER signals were located in diffuse B-cell lymphomas of the
ileocecal (11.1 %).
In conclusion, these finding demonstrate a rare association
between EBV and lower gastrointestinal lymphomas (excluding stomach).
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