| 要約: | Wound healing is a complex biological process that requires a series of concurrent physiological phases, such as haemostasis, inflammation, proliferation (granulation and epithelialisation) and remodelling (maturation). This healing process is coordinated by complicated cellular and molecular mechanisms involving different growth factors and cytokines. However, chronic metabolic diseases such as diabetes mellitus are known to cause chronic, non-healing wounds such as diabetic foot ulcers and pressure ulcers. Chronic wound pathophysiology often involves redox imbalance and inflammatory pathway dysregulation, sometimes with concurrent microbial infection. Redox imbalance is a phenomenon that increases free radical production and decreases the antioxidant defence mechanism in the body, as seen in diabetic foot ulcers and pressure ulcers where endogenous antioxidants like glutathione and tocopherols are significantly reduced or absent, indicating a severe oxidative imbalance causing tissue injury known as oxidative stress via lipid peroxidation of membranes and oxidation of essential proteins and enzymes. For this reason, there is a growing interest in the study of new wound-healing pharmaceuticals containing plant extracts having compounds with free radical scavenging properties that can effectively and significantly improve wound healing and protect against oxidative stress. This current research focuses on developing and evaluating an extract gel of curcuma aromatica (c. Aromatica) rhizomes for wound healing in diabetic and non-diabetic mice models.
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