| Summary: | Alzheimer’s disease (ad) is a neurodegenerative disorder associated with ageing. It is characterised by beta-amyloid deposition, aggregation of neurofibrillary tangles, oxidative stress and decreased acetylcholine levels. Horsfieldia species, known for their medicinal properties, have yielded secondary metabolites with various health benefits. This research highlighted the emergence of various secondary metabolites coupled with a considerable amount of phenolic and flavonoid constituents in the extracts of h. Polyspherula and h. Tomentosa. A total of seventeen unique compounds were isolated, ten of which were from the ethyl acetate (etoac) extract of the bark of h. Polyspherula, while another seven from the etoac extract of h. Tomentosa fruit. Hence, the isolated compounds from h. Polyspherula are; 3,4-dihydroxybenzoic acid (85), 16-phenylhexadecanoic acid (86), undecylbenzene (87), lauric acid (88), myristic acid (89), pentadecanoic acid (90), 1-tridecene (91), trimyristin (92), δ-tocotrienol (93) and stigmasterol (94). Meanwhile, for h. Tomentosa, the isolated compounds include trimyristin (92), (-)-sesamin (95), 1-(2,4,6-trihydroxyphenyl)decan-1-one (96), 1-(2,4,6-trihydroxyphenyl)-12-phenyl-dodecan-one (97), 1-(2,6-dihydroxy-4-(octylo-xy)phenyl)-11-undecan-1-one (98), 9-octyl-sesamin (99) and methyl myristate (100), three of which 97-99 are new.
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