Outcome Following First Radioiodine Therapy For Remnant Ablation Of Low-risk Differentiated Thyroid Cancer At Institut Kanser Negara (Ikn)
Purpose: The role of remnant radioiodine ablation (RRA) in post-total thyroidectomy low-risk differentiated thyroid cancer (DTC) has been a debatable issue among experts over the decades. Giving that the risk of disease-specific death is less than 1% as well as only 2% - 3% risk of persistent or rec...
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| Format: | Thesis |
| Language: | English |
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2023
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| Online Access: | http://eprints.usm.my/63795/ |
| Abstract | Abstract here |
| Summary: | Purpose: The role of remnant radioiodine ablation (RRA) in post-total thyroidectomy low-risk differentiated thyroid cancer (DTC) has been a debatable issue among experts over the decades. Giving that the risk of disease-specific death is less than 1% as well as only 2% - 3% risk of persistent or recurrent disease in low-risk DTC, the role of giving radioactive iodine therapy (RAIT) remains in the grey area. This study is to evaluate the outcome of RRA in low-risk DTC and to identify the possible affecting factors that may result in unsuccessful RRA in low-risk DTC.
Methodology: A retrospective study of 212 patients with low-risk DTC treated with radioiodine-131 (I-131) with activities of 100 mCi and below from January 2017 to December 2020 at Nuclear Medicine Department, Institut Kanser Negara (IKN) with varying factors were identified to determine outcome following RRA in our centre. The outcome of a successful RRA was determined by negative diagnostic radioiodine-131 whole body scan (I-131 WBS) and endogenous thyrotrophin-stimulated serum thyroglobulin of (sTg) 1.0 ng/mL at two consecutive follow-up 6 to 12 months after RRA. sTg cut-off value was determined by using receiver operating characteristic (ROC) curve. The association of risk factors that may affect the successful RRA in low-risk DTC were determined using univariate and multiple logistic regression analysis. |
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