Expression of ron tyrosin kinase receptor on breast cancer cell lines
Also available in printed version : TP248.25.C44 K43 2013 raf
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| Format: | Bachelor thesis |
| Language: | ENG |
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Universiti Teknologi Malaysia
2025
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| Online Access: | https://utmik.utm.my/handle/123456789/106005 |
| Abstract | Abstract here |
| _version_ | 1852582454951411712 |
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| author | Khaled W. K. Alzeini |
| author2 | Salehhuddin Hamdan, supervisor |
| author_facet | Salehhuddin Hamdan, supervisor Khaled W. K. Alzeini |
| author_sort | Khaled W. K. Alzeini |
| description | Also available in printed version : TP248.25.C44 K43 2013 raf |
| format | Bachelor thesis |
| id | utm-123456789-106005 |
| institution | Universiti Teknologi Malaysia |
| language | ENG |
| publishDate | 2025 |
| publisher | Universiti Teknologi Malaysia |
| record_format | dspace |
| record_pdf | Abstract |
| spelling | utm-123456789-1060052025-08-21T02:28:10Z Expression of ron tyrosin kinase receptor on breast cancer cell lines Khaled W. K. Alzeini Salehhuddin Hamdan, supervisor Breast--Cancer Cell culture Also available in printed version : TP248.25.C44 K43 2013 raf RON receptor is one member of the MET family of receptor tyrosine kinases. When it is activated by its own ligand, macrophage stimulating protein (MSP), RON initiates a downstream signaling pathways which result of some function in the cell such as dissociation, migration, and invasion. Several RON variants that arise through mRNA splicing or by an alternate translational start site have been identified, some with oncogenic potential. The purpose of the present project was to determine the expression of RON receptor in two breast cancer cell lines since it is the most common distribution cancer in women around the world. MDA-MB-213 and MCF-7 breast cancer cell lines and WRL-68 embryonic liver as a normal cell line were used in this experiment to characterize the expression. The expression of RON receptor on the cell surface, the concentration of mRNA and the RON protein were done by utilizing Immunofluorescent staining (IF), polymerase chain reaction (PCR) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) respectively. Collectively, it was found that RON receptor was overexpressed in these two breast cancer cell lines comparing to the normal cell lines. atiff UTM 128 p. Thesis (Sarjana Sains (Bioteknologi)) - Universiti Teknologi Malaysia, 2013 2025-04-15T01:09:01Z 2025-04-15T01:09:01Z 2013-02 Bachelor thesis https://utmik.utm.my/handle/123456789/106005 valet-20140127-081618 vital:69994 ENG Restricted Closed Access UTM Complete Submitted Publication application/pdf Universiti Teknologi Malaysia |
| spellingShingle | Breast--Cancer Cell culture Khaled W. K. Alzeini Expression of ron tyrosin kinase receptor on breast cancer cell lines |
| title | Expression of ron tyrosin kinase receptor on breast cancer cell lines |
| title_full | Expression of ron tyrosin kinase receptor on breast cancer cell lines |
| title_fullStr | Expression of ron tyrosin kinase receptor on breast cancer cell lines |
| title_full_unstemmed | Expression of ron tyrosin kinase receptor on breast cancer cell lines |
| title_short | Expression of ron tyrosin kinase receptor on breast cancer cell lines |
| title_sort | expression of ron tyrosin kinase receptor on breast cancer cell lines |
| topic | Breast--Cancer Cell culture |
| url | https://utmik.utm.my/handle/123456789/106005 |
| work_keys_str_mv | AT khaledwkalzeini expressionofrontyrosinkinasereceptoronbreastcancercelllines |