Flow simulation of patent ductus arteriosus to evaluate hemodynamic flow and thrombosis formation on closure device
Also available in printed version
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| Format: | Master's thesis |
| Language: | English |
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Universiti Teknologi Malaysia
2025
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| Online Access: | https://utmik.utm.my/handle/123456789/44549 |
| Abstract | Abstract here |
| _version_ | 1855605564789227520 |
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| author | Nurus Sa�adah Bachok |
| author2 | Ahmad Zahran Md. Khudzar, supervisor |
| author_facet | Ahmad Zahran Md. Khudzar, supervisor Nurus Sa�adah Bachok |
| author_sort | Nurus Sa�adah Bachok |
| description | Also available in printed version |
| format | Master's thesis |
| id | utm-123456789-44549 |
| institution | Universiti Teknologi Malaysia |
| language | English |
| publishDate | 2025 |
| publisher | Universiti Teknologi Malaysia |
| record_format | DSpace |
| record_pdf | Restricted |
| spelling | utm-123456789-445492025-08-21T02:40:40Z Flow simulation of patent ductus arteriosus to evaluate hemodynamic flow and thrombosis formation on closure device Nurus Sa�adah Bachok Ahmad Zahran Md. Khudzar, supervisor Biomedical engineering and health sciences Also available in printed version Patent Ductus Arteriosus (PDA) is a bridge between pulmonary artery and aorta where it fails to closed after birth where infants are mostly affected which will lead to death if not treated. Transcatheter closure using occlusion device is commonly used as a treatment to close the shunt. Various design of occluder affect the flow of blood in the duct. In order to design ideal occluder, hemodynamic flow pattern need to be studied. Time average wall shear stress (TAWSS) and oscillatory shear index (OSI) are useful parameter to predict thrombus formation in occluder since it is expensive and impossible to study using in-vitro and in-vivo procedure. Convex and hemispherical shape of occluder attach to aorta was used in this study. Blood was simulated as Newtonian with incompressible and laminar flow. A computational fluid dynamic (CFD) study has been done in pulsatile blood flow through the aortic arch and the occluder. Convex shape of occluder yield more TAWSSlow <0.5Pa at 29.25% and higher OSI value at 51.44%. In contrast, hemispherical shape of occluder generated 1.75% of TAWSSlow <0.5Pa and lower OSI at 43.07%. Hence, from this preliminary work on PDA, it is recommended that convex shape of occluder promote thrombus formation faster and much better compared to hemispherical shape. fahmimoksen UTM 74 p. Thesis (Sarjana Falsafah (Kejuruteraan Bioperubatan)) - Universiti Teknologi Malaysia, 2020 2025-03-11T06:22:12Z 2025-03-11T06:22:12Z 2020 Master's thesis https://utmik.utm.my/handle/123456789/44549 vital:144866 valet-20211221-102959 ENG Closed Access UTM Complete Unpublished Completion application/pdf Universiti Teknologi Malaysia |
| spellingShingle | Biomedical engineering and health sciences Nurus Sa�adah Bachok Flow simulation of patent ductus arteriosus to evaluate hemodynamic flow and thrombosis formation on closure device |
| thesis_level | Master |
| title | Flow simulation of patent ductus arteriosus to evaluate hemodynamic flow and thrombosis formation on closure device |
| title_full | Flow simulation of patent ductus arteriosus to evaluate hemodynamic flow and thrombosis formation on closure device |
| title_fullStr | Flow simulation of patent ductus arteriosus to evaluate hemodynamic flow and thrombosis formation on closure device |
| title_full_unstemmed | Flow simulation of patent ductus arteriosus to evaluate hemodynamic flow and thrombosis formation on closure device |
| title_short | Flow simulation of patent ductus arteriosus to evaluate hemodynamic flow and thrombosis formation on closure device |
| title_sort | flow simulation of patent ductus arteriosus to evaluate hemodynamic flow and thrombosis formation on closure device |
| topic | Biomedical engineering and health sciences |
| url | https://utmik.utm.my/handle/123456789/44549 |
| work_keys_str_mv | AT nurussaadahbachok flowsimulationofpatentductusarteriosustoevaluatehemodynamicflowandthrombosisformationonclosuredevice |