Centella asiatica encapsulated silica aerogel and its application as antioxidant and antibacterial agents
Also available in printed version
| 第一著者: | |
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| その他の著者: | |
| フォーマット: | Master's thesis |
| 言語: | 英語 |
| 出版事項: |
Universiti Teknologi Malaysia
2025
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| 主題: | |
| オンライン･アクセス: | https://utmik.utm.my/handle/123456789/49845 |
| Abstract | Abstract here |
| _version_ | 1854975058447958016 |
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| author | Nurul Syakina Malek |
| author2 | Nik Ahmad Nizam Nik Malek, supervisor |
| author_facet | Nik Ahmad Nizam Nik Malek, supervisor Nurul Syakina Malek |
| author_sort | Nurul Syakina Malek |
| description | Also available in printed version |
| format | Master's thesis |
| id | utm-123456789-49845 |
| institution | Universiti Teknologi Malaysia |
| language | English |
| publishDate | 2025 |
| publisher | Universiti Teknologi Malaysia |
| record_format | dspace |
| record_pdf | Abstract |
| spelling | utm-123456789-498452025-08-20T21:13:37Z Centella asiatica encapsulated silica aerogel and its application as antioxidant and antibacterial agents Nurul Syakina Malek Nik Ahmad Nizam Nik Malek, supervisor Biosciences and medical engineering Also available in printed version Centella asiatica (CA) is one of the well-known herbs for antioxidant and antibacterial applications. However, it has limitations such as poor medicating doses of the extracted CA in the human body and easily degraded by the action of external sources like light or oxygen. Hence, CA encapsulated silica aerogel (SA) was developed in this study to preserve the bioactive compound of CA. The extracted form (0.3 and 100.0 mg/mL) and powder form (0.1, 1.0 and 5.0 g) of CA were encapsulated in SA via sol gel process from rice husk ash as silica source. CA encapsulated SA (CA-SA) samples were characterized using infrared spectroscopy, field emission scanning-electron microscopy, energy dispersive X-ray analyzer, X-ray diffraction, and Brunauer-Emmett-Teller surface analysis. The characterization had proven that the porous structure of SA encapsulated CA remained unchanged after the loading process. The antioxidant study was carried out using 2,2-diphenyl-1-picrylhydrazyl method and CA-SA extract showed a higher percentage of antioxidant activity than CA-SA powder. The antibacterial activity was tested against Escherichia coli ATCC 11229, Pseudomonas aeruginosa ATCC 15442, Staphylococcus aureus ATCC 6538 and Enterococcus faecalis ATCC 29212. Determination of antibacterial activity were performed by soaking SA, CA and all CA-SA samples in bacteria culture for 2 hours prior to the dropped plate technique. All CA-SA samples showed good antibacterial activity against S. aureus ATCC 6538. In conclusion, the encapsulation of CA into porous SA via sol-gel process was successfully synthesized with good application of CA-SA as new antioxidant and antibacterial agents fahmimoksen UTM 107 p. Thesis (Sarjana Sains (Biosains)) - Universiti Teknologi Malaysia, 2016 2025-03-13T06:53:11Z 2025-03-13T06:53:11Z 2016 Master's thesis https://utmik.utm.my/handle/123456789/49845 vital:114545 valet-20180910-094223 ENG Closed Access UTM Complete Unpublished Completion application/pdf Universiti Teknologi Malaysia |
| spellingShingle | Biosciences and medical engineering Nurul Syakina Malek Centella asiatica encapsulated silica aerogel and its application as antioxidant and antibacterial agents |
| thesis_level | Master |
| title | Centella asiatica encapsulated silica aerogel and its application as antioxidant and antibacterial agents |
| title_full | Centella asiatica encapsulated silica aerogel and its application as antioxidant and antibacterial agents |
| title_fullStr | Centella asiatica encapsulated silica aerogel and its application as antioxidant and antibacterial agents |
| title_full_unstemmed | Centella asiatica encapsulated silica aerogel and its application as antioxidant and antibacterial agents |
| title_short | Centella asiatica encapsulated silica aerogel and its application as antioxidant and antibacterial agents |
| title_sort | centella asiatica encapsulated silica aerogel and its application as antioxidant and antibacterial agents |
| topic | Biosciences and medical engineering |
| url | https://utmik.utm.my/handle/123456789/49845 |
| work_keys_str_mv | AT nurulsyakinamalek centellaasiaticaencapsulatedsilicaaerogelanditsapplicationasantioxidantandantibacterialagents |