Feasiliblity of a-mode ultrasound as a monitoring method of minimally invasive thermal theraphy for breast cancer
Also available in printed version
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | |
| التنسيق: | Bachelor thesis |
| اللغة: | الإنجليزية |
| منشور في: |
Universiti Teknologi Malaysia
2025
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://utmik.utm.my/handle/123456789/55764 |
| Abstract | Abstract here |
| _version_ | 1854975105301479424 |
|---|---|
| author | Dzulfadhli Saffuan Ridzuan |
| author2 | Maheza Irna Mohamad Salim, supervisor |
| author_facet | Maheza Irna Mohamad Salim, supervisor Dzulfadhli Saffuan Ridzuan |
| author_sort | Dzulfadhli Saffuan Ridzuan |
| description | Also available in printed version |
| format | Bachelor thesis |
| id | utm-123456789-55764 |
| institution | Universiti Teknologi Malaysia |
| language | English |
| publishDate | 2025 |
| publisher | Universiti Teknologi Malaysia |
| record_format | dspace |
| record_pdf | Abstract |
| spelling | utm-123456789-557642025-08-21T10:38:40Z Feasiliblity of a-mode ultrasound as a monitoring method of minimally invasive thermal theraphy for breast cancer Dzulfadhli Saffuan Ridzuan Maheza Irna Mohamad Salim, supervisor Biosciences and medical engineering Also available in printed version Minimally Invasive Thermal Therapy (MITT) is an effective way to destroy diseased breast tissues by using thermal effects and has a huge potential to replace surgery, radiation or chemotherapy. However, this therapy needs a real time monitoring to improve its ability in delivering heat consistently and in preventing damage to nearby tissue. Therefore, A-Mode ultrasound which offers a real-time monitoring method can be used during the treatment to visualize the changes in size and shape of the diseased tissues. In this study, the feasibility of A-Mode ultrasound as a monitoring method of MITT is investigated. A-Mode ultrasound involves only one dimension (1D) signal processing which enables a quantitative measurement on different types of breast tissue to be conducted faster than using the two dimensional (2D) ultrasound monitoring system. The methodology of this study involved the use of normal and DMBA-induced virgin female mice breast tissue as subjects. These breast tissues were heated at temperature of 37oC, 55oC and 65oC to mimic the MITT procedure and quickly exposed to ultrasound. Later, the correlation between different thermal intensity and ultrasonic attenuation coefficient were calculated in Matlab. Besides that, total protein content measurement was also investigated to find the correlation between attenuation and tissue denaturation level at different temperature range. The tissues were grouped according to their histology results, namely normal with a large predominance of cells (NPC), cancer with a large predominance of cells (CPC) and cancer with high collagen fiber content (CHF). Finally, the sensitivity level was measured by dividing the means value of attenuation coefficient to the protein denaturation level. From the result the attenuation coefficient of ultrasound measured after MITT is lower for tissues with large predominance of cells and increased with collagen fiber content. In this study, the CHF attenuates ultrasound at the highest rate, followed by NPC and CPC. Besides that, the total protein level of CHF was also higher compared to other groups after the MITT treatment. The ultrasound energy was attenuated further when it propagated through heated tissue as the temperature increased due to protein coagulation effects on those tissues. In conclusion A-Mode ultrasound can be used as monitoring method of MITT since the sensitivity of ultrasound attenuation to protein denaturation is different between normal tissues compared to cancerous tissue fahmimoksen UTM 60 p. Project Paper (Sarjana Muda Kejuruteraan (Bio-Perubatan)) - Universiti Teknologi Malaysia, 2014 2025-03-17T04:02:55Z 2025-03-17T04:02:55Z 2014 Bachelor thesis https://utmik.utm.my/handle/123456789/55764 valet-20170207-160229 vital:94881 ENG Closed Access UTM Complete Unpublished application/pdf Universiti Teknologi Malaysia |
| spellingShingle | Biosciences and medical engineering Dzulfadhli Saffuan Ridzuan Feasiliblity of a-mode ultrasound as a monitoring method of minimally invasive thermal theraphy for breast cancer |
| thesis_level | Other |
| title | Feasiliblity of a-mode ultrasound as a monitoring method of minimally invasive thermal theraphy for breast cancer |
| title_full | Feasiliblity of a-mode ultrasound as a monitoring method of minimally invasive thermal theraphy for breast cancer |
| title_fullStr | Feasiliblity of a-mode ultrasound as a monitoring method of minimally invasive thermal theraphy for breast cancer |
| title_full_unstemmed | Feasiliblity of a-mode ultrasound as a monitoring method of minimally invasive thermal theraphy for breast cancer |
| title_short | Feasiliblity of a-mode ultrasound as a monitoring method of minimally invasive thermal theraphy for breast cancer |
| title_sort | feasiliblity of a mode ultrasound as a monitoring method of minimally invasive thermal theraphy for breast cancer |
| topic | Biosciences and medical engineering |
| url | https://utmik.utm.my/handle/123456789/55764 |
| work_keys_str_mv | AT dzulfadhlisaffuanridzuan feasiliblityofamodeultrasoundasamonitoringmethodofminimallyinvasivethermaltheraphyforbreastcancer |