On-line glucose biosensor microfluidic device
Also available in printed version : RB45 N67 2012 raf
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| Format: | Bachelor thesis |
| Language: | English |
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Universiti Teknologi Malaysia
2025
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| Online Access: | https://utmik.utm.my/handle/123456789/60469 |
| Abstract | Abstract here |
| _version_ | 1854975046860144640 |
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| author | Norayati Nordin |
| author2 | Corcoles, Emma P., supervisor |
| author_facet | Corcoles, Emma P., supervisor Norayati Nordin |
| author_sort | Norayati Nordin |
| description | Also available in printed version : RB45 N67 2012 raf |
| format | Bachelor thesis |
| id | utm-123456789-60469 |
| institution | Universiti Teknologi Malaysia |
| language | English |
| publishDate | 2025 |
| publisher | Universiti Teknologi Malaysia |
| record_format | dspace |
| record_pdf | Abstract |
| spelling | utm-123456789-604692025-08-20T18:18:05Z On-line glucose biosensor microfluidic device Norayati Nordin Corcoles, Emma P., supervisor Blood sugar -- Analysis Biosensors Also available in printed version : RB45 N67 2012 raf Glucose detection has become an important fluid analysis in various clinical situations majorly in management and detection of diabetes mellitus. Continuous glucose measurements that provide tight glucose control and high data validity are more preferable for clinical practice. Biocompatibility of biosensors is still a problem for continuous in vivo detection. Microdialysis is a sampling technique that uses the concept of semi-permeable membrane to selectively sample the desired molecules and it is highly compatible with human tissue. This work aims to develop an on-line glucose biosensor microfluidic device. The device consists of an electrochemical glucose biosensor coupled on-line with microfluidic channel. The latter can be used as a connecting system between sampling devices and the biosensor or as a microdialysis probe itself for real time glucose concentration monitoring. The amperometric glucose biosensor is based on immobilization of ferrocene modified glucose oxidase (GOD) on the screen printed electrode surface with nafion film. The microfluidic channel was design with Solidwork software and fabricated using polydimethylsiloxane (PDMS). Cellulose acetate was used to fabricate a semipermeable membrane placed over the microfluidic channel, developing in this way a microdialysis channel. The glucose biosensor was tested for sensitivity, stability and selectivity. The microfluidic/microdialysis channel was characterized separately and in combination with the biosensor and this was tested for continuous, rapid real time monitoring of glucose concentration. On-line glucose biosensor microfluidic device would provide continuous data of glucose concentration and increase the efficiency in glucose management. This device can also be applied to various chemical signal other than glucose atiff UTM 65 p. Project Paper (Sarjana Muda Kejuruteraan (Bio - Perubatan)) - Universiti Teknologi Malaysia, 2012 2025-03-17T06:40:29Z 2025-03-17T06:40:29Z 2012 Bachelor thesis https://utmik.utm.my/handle/123456789/60469 valet-20171010-095224 vital:104519 ENG Closed Access UTM Complete Unpublished application/pdf Universiti Teknologi Malaysia |
| spellingShingle | Blood sugar -- Analysis Biosensors Norayati Nordin On-line glucose biosensor microfluidic device |
| thesis_level | Other |
| title | On-line glucose biosensor microfluidic device |
| title_full | On-line glucose biosensor microfluidic device |
| title_fullStr | On-line glucose biosensor microfluidic device |
| title_full_unstemmed | On-line glucose biosensor microfluidic device |
| title_short | On-line glucose biosensor microfluidic device |
| title_sort | on line glucose biosensor microfluidic device |
| topic | Blood sugar -- Analysis Biosensors |
| url | https://utmik.utm.my/handle/123456789/60469 |
| work_keys_str_mv | AT norayatinordin onlineglucosebiosensormicrofluidicdevice |