Suppression Effect of Eurycomanone on the Growth of Human Hepatoma Cells (Hepg2) by Inducing P53-Mediated Apoptotic Pathway

Eurycomanone is a compound found in Eurycoma longifolia Jack and has been reported that it had a cytotoxic effect against various cancer cell lines. The aim of this study was to isolate eurycomanone from the roots of E. longifolia, investigate the cytotoxicity against human hepatoma cell line, HepG2...

Full description

Bibliographic Details
Main Author:	Zakaria, Yusmazura
Format:	Thesis
Language:	English English
Published:	2009
Subjects:	Hepatoma
Online Access:	http://psasir.upm.edu.my/id/eprint/7234/1/IB_2009_8a.pdf

Similar Items

Suppression Effects of Pandanus Amarylfolius and Strobilanthes Cripus Extracts on the Growth of Breast Cancer Cells by Inducing p53-Mediated Apoptotic Pathway
by: Chong, Hueh Zan
Published: (2010)

Elucidation Of Erk1/2/C-Myc/P53 Signaling Pathways Involved In Andrographolide-Induced Antiproliferative Activity In Human Glioblastoma Dbtrg-05mg Cell Line
by: Othman, Nurul Syamimi
Published: (2023)

Involvement of endoplasmic reticulum stress-induced apoptotic pathway in cervical cancer cells treated with cytotoxic agents
by: Wan Abd Ghani, Wan Nor Hafiza
Published: (2014)

Enhancing human breast cancer cells destruction using combination of adenovirus P53 and hyperthermia treatment
by: Elengoe, Asita
Published: (2015)

Enhancing human breast cancer cells destruction using combination of adenovirus expressing P53 and hyperthermia treatment
by: Elengoe, Asita
Published: (2015)

The relationship of P53 gene mutation with clinicopathological characteristic in breast cancer
by: Amrank, Fitreena Anis
Published: (2016)

Cytotoxicity of Goniothalamin on the Human Hepatocellular Carcinoma HEPG2 Cell Line
by: Obaid Al-Qubaisi, Mothanna Sadiq
Published: (2009)

Gene Expression And Metabonomic Profilings In P53+/- Knockout Mice Following Diethylstilbestrol Treatment
by: Salleh, Mohd Nazil
Published: (2003)

Ki67 and p53 expression in relation to clinicopathological features in phyllodes tumour of the breast
by: Ali, Nurul Atiah Mohd
Published: (2020)

Cloning and Characterization of the Apoptotic Suppressor Gene P49 from Spodoptera Litura Nucleopolyhedrovirus
by: Mat Amin, Noriha
Published: (2005)

Properties of asiaticoside in suppressing hyperpermeability in human umbilical vein endothelial cells induced by interferon-gamma
by: Khairudin, Nurnabila Huda
Published: (2016)

Apoptotic-related signalling pathways in mcf-7 cells treated with ethyl acetate extract of dillenia suffruticosa, and isolation of its major compounds
by: Yin, Sim Tor
Published: (2015)

The Effects Of Eurycoma Longifolia Extract And Eurycomanone On The Steroidogenesis In Mouse Leydig Cells
by: Ahmed, Nor Amira Khurshid
Published: (2018)

Bioinformatics analysis of the structural and biochemical effect of the chemical weapon mustard gas on the P53 protein and cell death
by: Esmaili, Rita
Published: (2013)

Effects of Trichoderma-Induced Suppressive Soil on Fusarium Wilt of Tomato
by: Said, Rozlianah Fitri
Published: (2005)

Marine riser vortex induced vibration (VIV) suppression device
by: Muhamat Yain, Nursahliza
Published: (2017)

Single nucleotide polymorphisms of p53, p21, CYP1A1, FAS, and Benzo(α)pyrene as risk factors in cervical carcinoma
by: Tan, Yee Hock
Published: (2017)

A process engineering approach to the standardization of eurycomanone in eurycoma longifolia water extract
by: Kumaresan, Sivakumar
Published: (2008)

Cytotoxic, anti-proliferative and apoptotic effects of zerumbone on human and mouse leukemic cell lines
by: Hamid, Asmah
Published: (2010)

Study On The Effects Of Catharanthus Roseus-silver Nanoparticles On Human Hepatocellular Carcinoma Cell Line Hepg2
by: Azhar, Nur Asna
Published: (2024)

Reverse Transcriptase in Situ Expression Patterns of P53, Cyclin E And Rb Genes at Different Stages of Breast Cancer
by: Zamanian, Mohammadreza
Published: (2007)

Optimization of ultrasound and enzyme assisted extraction of eurycomanone from eurycoma longifolia (tongkat ali)
by: Yuhai, He
Published: (2018)

Cytotoxic Effect of Girinimbine on HepG2 Cells
by: Mohan, Suvita Syam
Published: (2011)

Morphological changes in liver cells of hypercholesterolaemic-induced rats and hepG2 cell lines associated with edible bird’s nest supplementation
by: Mohd Noor, Mohd Akmal
Published: (2020)

Antitumor effects of zerumbone on rat hepatocarcinoma and HEPG2 cells
by: Taha, Manal Mohamed Elhassan
Published: (2011)

Human Hepatitis B Viral Proteins HBX and HBE: Roles in HepG2 Cell Line Survival and Cell Death
by: Holme, Andrea Lisa
Published: (2004)

The effect of Tinospora crispa crude methanolic extract on hepatoma G2 cell line and wistar rats insulin resistance model / Mohd Nazri Abu
by: Abu, Mohd Nazri
Published: (2019)

Correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma
by: Abd Alabbas, Haider K.
Published: (2012)

Signalling pathways involved in IL-8 mediated odontogenic differentiation of shed cultured on human amniotic membrane with BMP-2
by: Osman, Zul Faizuddin
Published: (2021)

The Cytochrome P450 Inhibitory Effects Of Andrographolide And 14-Deoxy-11,12- Didehydroandrographolide In HEPG2 Cells: Development Of Model In Vitro Studies Ofdrug-Herb Interactions
by: Ooi , Jer Ping
Published: (2010)

Expressions of angiogenic markers and apoptotic markers in soft tissue sarcoma
by: Yusuf, Yusri
Published: (2010)

The effect of Clinacanthus nutans root extracts on the expression of apoptotic genes
by: Grace P. Kaling
Published: (2014)

Quality Control Analysis, Standardization And Stability Studies Of Eurycoma Longifolia And Effect Of Its Saponin Content On Solubility And Toxicity Of Eurycomanone
by: Khari, Nursyazura
Published: (2014)

Antibacterial and antioxidant activities of Piper cubeba L. berries extract and its cytotoxicity effect on 3T3 human fibroblast and HEPG2 cell lines
by: Lou, Shuai Qiang
Published: (2021)

Cytotoxic and apoptotic effects of curcumin and thymoquinone on HSC-2 cell line
by: Saleem, Khadeeja
Published: (2021)

Modulation of amygdalar glutamatergic neurotransmission during ethanol withdrawal induced anxiety-like syndrome via MGluR5-PKC epsilon mediated signalling pathway
by: A/L Murthy, Jayakumar
Published: (2015)

Characterisation of erythropoietin gene-modified human mesenchymal stem cells and anti-apoptotic effect of glutamate excitotoxicity in a retinal neuron cell line
by: Shirley, Ding Suet Lee
Published: (2017)

Genetic variability and selection of high root yield and high eurycomanone content genotypes in Malaysian tongkat ali (Eurycoma longifolia Jack) germplasm
by: Govindasamy, Sentoor Kumeran
Published: (2014)

Production and characterization of phycobiliproteins from cyanobacteria and their effects on HepG2 cancer cell lines
by: Begium, Hasina
Published: (2014)

Modeling the information pathways in human brain during motor task with concurrent visual stimulation
by: Ramli, Sofia Najwa
Published: (2010)