p53-Mdm2 interaction targeted therapy by Nutlin-3 on nasopharyngeal carcinoma cells / Voon Yee Lin

Nutlin-3, a small-molecule inhibitor of p53-Mdm2 interaction, is known to be effective against cancers expressing wild-type (wt) p53. p53 mutations are rare in nasopharyngeal carcinoma (NPC), and hence targeting the disruption of p53-Mdm2 interaction to reactivate p53 may offer a promising therap...

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Bibliographic Details
Main Author:	Voon, Yee Lin
Format:	Thesis
Published:	2016
Subjects:	RC0254 Neoplasms. Tumors. Oncology (including Cancer)

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