Evaluation Of Toxicity, Pharmacokinetic And Clastogenicity Profile Of Ethyl 2-[4[(Piperidin-1-yl) Phenyl]-1h-benzimidazole-5-carboxylate (Bzd9l1), Novel Sirtuin Inhibitor

The mammalian sirtuins (SIRTs) have been linked to various diseases including cancer, diabetes, neurodegenerative and cardiovascular diseases. Thus, SIRTs are attractive targets for the development of pharmaceuticals. The lack of potential SIRT inhibitors in cancer clinical trials highlights the nee...

Full description

Bibliographic Details
Main Author:	Lee, Yeuan Ting
Format:	Thesis
Language:	English
Published:	2022
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/59372/
Abstract	Abstract here

Similar Items

Mechanism Of Action Of A Benzimidazole Sirtuin Inhibitor, Bzd9l1, In Colorectal Cancer
by: Tan, Yi Jer
Published: (2022)

Synthesis And Biological Activity Of Benzimidazole Analogs As Sirtuin Enzyme Inhibitors
by: Yeong, Keng Yoon
Published: (2016)

Bzd9l1: Elucidation Of Its Anti-angiogenic Potential In In-vitro And In-vivo Colorectal Cancer Models
by: Subramaniam, Ayappa V.
Published: (2023)

Pharmacokinetics And Metabolism Studies Of Antifilarial Drugs Derivatives Of Benzimidazole Carbamate
by: Ramanathan, Surash
Published: (1996)

The structure and electronic properties of new ruthenium complexes with 1-benzoyl-3-(pyridine-2-yl)-1h-pyrazole as potential photosensitiser
by: Mark Lee Wun Fui (P72599)
Published: (2023)

Antinociceptive and anti inflammatory activities of 3-(2,5 dimethoxyphenyl)-1-(5 methylfuran-2-YL) prop-2-en-1 in mice
by: Abu Bakar, Noor Azlina
Published: (2016)

Functional analysis of Arabidopsis thaliana 1-aminocyclopropane-1-carboxylic acid oxidase gene in response to limited water
by: Ismawanto, Sigit
Published: (2013)

Antinociceptive effect of 3-(2, 3 dimethoxyphenyl)-1(methylfuran-2-yl) prop-2-en-1-one in mice and its mechanisms of action
by: Ismail, Nur Izzati
Published: (2015)

Optimising The Production Of Chiral Alcohol Via Aspergillus Niger Catalysed Biotransformation Of 1-(4-Bromo-Phenyl)-Ethanone
by: Abas, Fatimatul Zaharah
Published: (2011)

Benzimidazole derivatives as potential dual inhibitors for poly (adp-ribose) polymerase-1 and dihydroorotate dehydrogenase / Iskandar Abdullah
by: Iskandar, Abdullah
Published: (2015)

Mechanism of the Anti-Inflammatory Action of 3-(2-Hydroxy-Phenyl)-1-(5-Methyl-Furan 2-y-l) Propenone (HMP).
by: Liew, Choi Yi
Published: (2010)

The synthesis of oseltamivir phosphate key intermediate, tert-butyl (5-(pentan-3-yloxy)-6- ((trimethylsilyl)oxy)cycloh ex-3-en-1-yl)carbamate and synthesis of (1S,2S)- hydroxycyclohexene-1,2,3- triazole derivatives / Sufi An-Nur Abd Haris
by: Abd Haris, Sufi An-Nur
Published: (2022)

Investigation Of The Anti-Proliferative Effect Of Synthetic 1-[(Bromomethyl)(phenyl) methyl]-2-(2,4dinitrophenyl)hydrazine Derivative On Cervical Cancer Cells
by: Othuman, Faiqah Husna Shaik
Published: (2016)

Investigation Of The Anti-Proliferative Effect Of Synthetic 1-[(Bromomethyl)(Phenyl) Methyl]-2-(2,4-Dinitrophenyl)Hydrazine Derivative On Cervical Cancer Cells
by: Shaik Othuman, Faiqah Husna
Published: (2016)

Anti-inflammatory properties of 3-(2,5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one (L31) in lung epithelial cells and on airway inflammation in a murine model of asthma
by: Rajajendram, Revathee
Published: (2014)

Pretreatment of oil palm lignocellulosic biomass using 1-ethyl-3-methylimidazolium acetate / Intan Suhada Azmi
by: Azmi, Intan Suhada
Published: (2018)

Development of thulium fiber lasers operating at 1.9 micron region
by: Dess Iskandar Md Zen
Published: (2025)

Medicinal potential of 3,4,5-Trihydroxy-N-O-[(2 Methyl-1H-INdoL-3-YL)-Methylidene] benzohydrazide / Faezeh Tayeby
by: Faezeh , Tayeby
Published: (2017)

Study of thermal performance and properties of 1-pyrene carboxylic-acid functionalized graphene nanofluids in a heat pipe / Alireza Esmaeilzadeh
by: Alireza , Esmaeilzadeh
Published: (2022)

Vascular reactivity, chemical profile, toxicological and pharmacokinetic studies of andrographis paniculata nees extracts [RS1-441].
by: Raghava Naidu, Sriramaneni
Published: (2009)

Association of matrix metalloproteinase-1, 9, 12 and tissue inhibitor of metalloproteinase-1 gene polymorphisms in malay male essential hypertensive subject
by: Tabatabaee, Farizeh Aalam Ghomi
Published: (2015)

Penentuan Metilasi Dna Pada Promoter Matrix Metalloproteinase 1 (MMP1) Dan MMP 9 Dalam Kelahiran Bayi Pramatang
by: Nurul Hayati Mohamad Zainal (P50275)
Published: (2023)

Combinatorial Crispr/Cas9 For Suppression Of Latent Hiv-1 Provirus In Vitro
by: Ravichantar, Nithya
Published: (2020)

Conversion of glycerol to glycerol carbonate via transesterification using 1-Ethyl-3-Methylimidazolium acetate catalyst / Zati Ismah Ishak
by: Zati Ismah, Ishak
Published: (2018)

Wound healing potential of copper (II) bis [n'- (5-chloro-1hindol-3-yl) methyl nicotinic hydrazide] on experimentally induced excision wounds in rats / Morvarid Rahnama
by: Rahnama, Morvarid
Published: (2013)

Digital orthophoto production of aerial photograph using pci geomatica software version 9.1
by: Noraini Zainal Abidin
Published: (2025)

CB1-mediated effects of delta-9-tetrahydrocannabinol (Δ9THC) on neuronal protein expressions in the hippocampus of male sprague dawley rats
by: Zakaria, Fatin Nadzirah
Published: (2013)

Synthesis, characterization and antioxidant activities of ni(ii) cu(ii), and zn(ii) complexes of substituted 4-phenyl-1,3,5-triazine-2,6- salicylaldimine / Abdulaziz Ali Alomari
by: Alomari, Abdulaziz Ali
Published: (2012)

Matrix Metalloproteinase -9 and Tissue Inhibitors of Metalloproteinasr-1 and -2 as Potential Novel Biomakers in Gestational Hypertension
by: Ab Hamid, Jabrullah
Published: (2010)

Evaluation of genetic alterations of IDH1, TP53 and CASP9 genes as biomarkers in glioma patients
by: Yit, Pua Jing
Published: (2022)

Pencirian gen Delta-endotoksin cry1B bacillus thuringiensis subsp. entomocidus HD-9.
by: Mohd Nor b Mat Isa
Published: (2023)

Differential Expression of Salivary MMP-8, MMP-9 and IL-1β for Staging of Periodontal Diseases
by: Muhammad Khairin Bin Mohd Hanafiah
Published: (2025)

Pencirian gen delta-endotoksin cry1B Bacillus thuringiensis subsp. entomocidus HD-9.
by: Mohd Noor Mat Isa
Published: (2023)

Synthesis, characterization and electrochemical investigation of limn1.9ti0.1-xsnxo4 spinel cathode materials for lithium-ion batteries / Aida Fazliza Mat Fadzil
by: Mat Fadzil, Aida Fazliza
Published: (2020)

Kajian Arkeologi Di Tapak SB1 R, SB1S, SB1T, SB1U, SB1V Dan SB1Z Di Kompleks Sungai Batu, Lembah Bujang, Kedah
by: Ahmad, Nurashiken
Published: (2016)

The implication of the polymorphism of COX-1, UGT1A6, and CYP2C9 among cardiovascular disease (CVD) patients treated with aspirin / Nur Jalinna Abdul Jalil
by: Abdul Jalil, Nur Jalinna
Published: (2014)

Prediction Model for H1N1 Disease
by: Ling, Amy Mei Yin
Published: (2011)

Development of thulium-doped and co-doped fiber lasers for 1.9 micron region operation / Norazlina Saidin
by: Norazlina, Saidin
Published: (2015)

Risk factors and genetic polymorphisms of GSTM1, GSTT1 and CYP1A1 in development of oral cancer in an indonesian population / Rahmi Amtha
by: Amtha, Rahmi
Published: (2007)

TESTING 1
by: Testing Author1
Published: (2024)